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18 Cards in this Set
- Front
- Back
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2 types of adrenocorticosteroids?
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1) Glucocorticoids
2) Mineralcorticoids |
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Where from the adrenal gland are corticosteroids produces?
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The Cortex - NOT the medulla
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Primary mineralcorticoid?
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Aldosterone
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Primary glucocorticoid?
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Cortisol
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Primary sex hormone steroid(s)?
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1) Testosterone
2) Estrogen |
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2 hormones responsible for the glucocorticoid synthesis?
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1) CRH (corticotropin releasing hormone)
2) ACTH (adrenocorticotropic hormone) |
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Describe the negative feedback loop of glucocorticoid synthesis
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The hypothalamus releases CRH which then stimulates the anterior pituatary. The anterior pituitary releases ACTH which stimulates the adrenal cortex. The adrenal cortex then releases cortisol. CORTISOL is the responsible for inhibiting both the hypothalamus and the ant. pituitary gland THUS the negative feed back loop.
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When is glucocorticoid release the highest?
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When one is waking up. It's release is cyclical.
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Primary function of cortisol?
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1) Control glucose
2) Control metabolism 3) Controls body's ability to deal with stress |
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Secondary functions of cortisol?
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1) decrease inflammation
2) suppress immune system |
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Where is the glucocorticoid receptor located?
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intracellular
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How does the glucocorticoid affect protein synthesis?
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The GC receptor complex changes DNA transcription within the nucleus.
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3 indications for glucocorticoid use?
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1) Endocrine conditions
2) Primary and secondary insufficiencies 3) Nonendocrine conditions |
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Types of nonendocrine conditions that may warrant use of cortisol?
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1) Inflammation
2) Immunesuppression 3) and sometimes as a antilymphocytic |
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Adrenocortical suppression
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Decreased or absent production of glucocorticoids d/t -FB effect
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Symptoms of Cushing Syndrome?
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1) Roud, puffy face
2) Trunk fat deposition 3) Muscle wasting 4) Excess hair 5) Osteoporosis 6) Glucose intolerance |
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Adverse effects of glucocorticoids
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1) Breakdown of supportive tissue
2) Peptic ulcer 3) HTN 4) Growth retardation 5) Glaucoma 6) Mood changes & psychosis 7) Susceptible to infection 8) Cataracts 9) Aggravation of DM |
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Primary function of aldosterone?
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Maintain fluid and electrolyte balance
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