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17 Cards in this Set
- Front
- Back
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Prednisone
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Has glucocorticoid and some mineralocorticoid activity.
Used in replacement therapy for Addison's disease or longer term therapy during adrenal suppression Prednisone is metabolically activated to prednisolone. |
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Bexamethasone
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More potent anti-inflammatory
Long half life (36-54 hrs) |
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Dexamethasone
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More potent anti-inflammatory
Long half life (36-54 hrs) Potent inhibitor of ACTH release Used to diagnose Cushing's syndrome |
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Beclomethasone
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Topical anti-inflammatory agents
Used for seasonal allergies and asthma via nasal spray/inhalers Poorly absorbed so systemic effects are minimal |
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Flunisolide
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Topical anti-inflammatory agents
Used for seasonal allergies and asthma via nasal spray/inhalers Poorly absorbed so systemic effects are minimal |
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Mometasone
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Topical anti-inflammatory agents
Used for seasonal allergies and asthma via nasal spray/inhalers Poorly absorbed so systemic effects are minimal |
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Mitotane
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Glucocorticoid antagonist similar to DDT
Reduces production of corticosteroids |
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Amphenone B
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Glucocorticoid antagonist
Reduces production of corticosteroids More potent, more toxic than mitotane |
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Metyrapone
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Glucocorticoid antagonist
Blocks 11 hydroxylation to prevent synthesis of cortisol and corticosterone 11 deoxycortisol does not inhibit pituitary and increases ACTH production and release |
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Aminoglutethimide
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Glucocorticoid antagonist
Blocks conversion of cholesterol to pregnenolone Blocks productiono of all adrenal steroids |
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Ketoconazole
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Glucocorticoid antagonist
Antifungal Non-selective inhibitor of steroid synthesis |
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Mifepristone (RU-486)
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Glucocorticoid antagonist
Antagonizes progesterone, glucocorticoid, and sex steroids (testosterone, estradiol) recepotrs in that order With or without misoprostol (prostglandin E2 analog), mifepristone is used to promote spontaneous abortion |
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Aldosterone
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Natural mineralocorticoid
Increases number of Na channels in apical membrane of distal tubule Promotes Na reabsorption at expense of K Promotes reabsorption of H2O and HCO3 Used in replacement therapy for Addison's disease May cause edema, HTN, CHF, hypokalemia, and alkalosis (HCO3 retention) |
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Desoxycorticosterone
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Mineralocorticoid
Naturally produced in zona fasciculata |
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Fludrocortisone
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Synthetiic mineralocorticoid
Most commonly used Potent mineralocorticoid, low glucocorticoid activity |
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Spironolactone
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Mineralocorticoid antagonist
Competes with aldosterone for receptors K sparing diuretic Acts on androgen receptors |
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Eplerenone
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Mineralocorticoid antagonist
Competes with aldosterone for receptors K sparing diuretic |
