Adrenergic Receptors

Front 1

2 types of Adrenergic receptors

Back 1

Alpha and beta receptors

Front 2

Alpha 1 receptors G protein

Back 2

Gq

Front 3

Alpha 2 G protein

Back 3

Gi

Front 4

Beta 1&2 g protein

Back 4

Gs

Front 5

Alpha 1 receptor locations

Back 5

Eye

Bladder

Blood vessels

Front 6

Alpha 2 receptor locations

Back 6

Pancreas

Prejunctional synapse

Front 7

Beta 1 receptor locations

Back 7

Heart

Front 8

Beta 2 receptor locations

Back 8

Lungs

GI

Pancreas

Front 9

Alpha 1 activation

Back 9

Mydraisis

Vasoconstriction

Urinary retention

Front 10

Alpha 2 activation

Back 10

Decrease insulin secretion

Decrease I'm NT release

Front 11

Beta 1 receptor activation

Back 11

Increased HR

Front 12

Beta 2 receptor activation

Back 12

Bronchodilation

Vasodilation

Increase GI motility

Increased insulin

Front 13

Albuterol receptor

Back 13

B2

Front 14

Isoproterenol

Back 14

Receptors: B1&2

- catecholamines

- less adverse side effects than epi n norepi

Front 15

Epinephrine receptor

Back 15

A1&2 B1&2

Front 16

Drugs capable of A1 activation

Back 16

Epi

Norepi

Dopamine

Phenylephrine

Front 17

A1 =?

Back 17

Vasoconstriction

Front 18

B1 =?

Back 18

Heart

Front 19

B2 =?

Back 19

Lungs

Front 20

Therapeutic effect B1 activation

Back 20

HF

Shock

Improve tissue perfusion

AV block

Front 21

Adverse effect B1

Back 21

Angina pectoris

Dysrhythmia

Front 22

Therapeutic application B2 activation

Back 22

Asthma (Bronchodilation)

Preterm labor (uterine relaxation)

Front 23

B2 activation adverse effecrs

Back 23

Hyperglycemia (in pts with diabetes)

Tremors

Front 24

Epi side effects

Back 24

Hypertensive crisis

Front 25

Catecholamines

Back 25

Epi, norepi, dopamine

Front 26

Norepi Therapeutic uses

Back 26

Hypotension

Cardiac arrest

Front 27

Difference btwn norepi n epi

Back 27

- doesn't activate B2 receptors

Front 28

Norepi n epi interactions

Back 28

MAOIs

TCA

Adrenergic blocking agents

Front 29

Isoproterenol

Back 29

Has few adverse effects than epi n norepi

- same drug interactions

Front 30

Catecholamines v. Noncatecolamines

Back 30

Front 31

Adrenergic antagonist

Back 31

Directly blocks adrenergic receptors

- all have reversible effects

- more selective than agonist

Front 32

2 types of adrenergic antagonists

Back 32

Alpha adrenergic blocker

Beta adrenergic blocker

Front 33

Therapeutic effects of alpha blockade

Back 33

- Tx of primary HTN (Vasodilation: A1 receptor blockade)

- antidote to overdose of alpha adrenergic agonist

- BPH

- Pheochromocytoma (secrete alot of catecholamines Increasing BP)

- Raynauds

Front 34

Adverse effects of A1 blockade

Back 34

Orthostatic HTN

Reflex tachycardia

Na+ retention

Front 35

Prazosin

Back 35

Competitive agonist

- Tx of HTN

Front 36

Tamsulosin (flowmax)

Back 36

Tx of BPH

Alpha 1 antagonist

Front 37

Beta adrenergic antagonist 1 Therapeutic application

Back 37

- HTN

- cardiac dysrythymia

- MI

- HF

- hyperthyroidism

- stage fright

- Glaucoma

Front 38

Metropolol

Back 38

Beta blocker

- Chosen over non selective beta blockers bc of diabetes n asthma pts

Front 39

B2 activation and Hypokalemia in diabetics

Back 39

- B2 receptors increase breakdown of glycogen to glucose

- In diabetic pts cnt maintain blood glucose balance

Front 40

MAOs

Back 40

One of the enzymes that inactivate epi and other catecholamines

** pt taking MAOIs shouldn't have epi (prolongs effects)

Front 41

Ephedrine

Back 41

Receptors: Alphas n betas

Mixed acting drug

Noncatecolamine

Activation when binder to alpha n beta sites