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9 Cards in this Set
- Front
- Back
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Adrenergic drugs affect receptors stimulated by ___________.
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nor-epinephrine and Ep
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Phenylethylamines that lack -OH group on ring and B hydroxyl group act by ________.
ie. drug |
act by causing a release of NE from nerve terminals (indirectly)
ie. AMPHETAMINE |
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absence of -OH on phenyl ring makes molecule more ________ and increased distribution in _______.
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more lipophilic --> cross BBB (CNS)
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compounds without one or both -OH groups are NOT substrates of _______.
What is the significance? |
not substrates of COMT--> increases bioavailibility --> prolongs duration of action
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-OH groups in position 3 and 5 confer _____ selectivity.
ie. drug |
confer beta2 selectivity
ie. TURBUTALINE |
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substitution on the alpha carbon atom block oxidation by ______ --> prolongs duration
ie. drugs (2) |
block oxidation by MAO
ie. AMPHETAMINE EPHEDRINE |
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identify 4 direct acting agonists
MOA |
EPINEPHRINE
NOREPINEPHRINE ISOPROTERENOL PHENYLEPHRINE acts DIRECTLY on a&b adrenoreceptors |
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identify 2 indirect acting agonists
MOA |
AMPHETAMINE
TYRAMINE taken into presynaptic neuron --> release of NE |
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identify 2 mixed action agonists
MOA |
EPHEDRINE
METARAMINOL activate adrenoceptors and releases NE |
