Adrenergic Drugs

Front 1

Reserpine

Back 1

Antihypertensive
-Loss NE stores ANS/CNS
-Blocks NE carrier of synaptic vessicles permitting NE to accum in cytosol where MAO metablizes it
-Impairs transport of DA by synaptic vesicles imparing synth of NE
-Depleting DA/Serotonin/Histamine(plateles)
-Parasymp not impaired (miosis,excessive salivation, gastric hypersec,peptic ulceration,bradycardia)
-depression/tremors

Front 2

Guanethidine

Back 2

Antihypertensive
1. Enters symp nuerons via NET nad blocks transmission (acute)
2. Blocks NET (acute)
3. Reduces NE stores (chronic)

Front 3

Methyldopa

Back 3

Antihypertensive
metabolized to amethylNE. Much higher affinity for a than b receptors.
- In JG and CNS reduce symp nerve act originating in CNS adn reduce renin secretion cause fall in BP.

Front 4

Desipramine

Back 4

Antidepressant
potent inhibitor of NET enhances actions of NE.
tremor,insomnia,blurred vision

Front 5

cocaine

Back 5

Reversibly binds NET blcoks uptake of NE and EPI potentiation of NE adn EPI

Front 6

Amphetimines

Back 6

Control Narcolepsy and ADD

Front 7

Antiasthmatics

Back 7

EPI and ISO potent B2 rec agonist causer relax of bronchial SM. Epi used in sever cases. Ephedrine also used for asthma and chronic bronchitis. ISO not used due to cardiac stimulation.

Front 8

Urticaria

Back 8

Epinephrine

Front 9

Nasal Decongestant

Back 9

Phenyephrine, Naphazoline

Front 10

Mydriatic Agent

Back 10

Phenylephrine, ephedrine

Front 11

tyramine,amphetamine,ephedrine action

Back 11

Release NE from sympathetic nuerons. Indirectly acting adrenergic drugs. DBH and other vesicle contents not released along w/ NE.
Tyramine- metabolized by MAO does not penetrate CNS
Amphetamine/Ephedrine-high affinity for MAO poor substrates accumulate in nerves and prevent NE from being oxidized. Penetrated CNS

Front 12

Phenoxybenzamine (haloalkyamine)

Back 12

noncompetitive irreversible a-adrenergic antagonist.
Nonspecific blocks 5-HT,ACh, and histamine rec as well.
Used in mamagement of pheochromocytoma-sever hypertension.

Front 13

Phentolamine (Imidazolins)

Back 13

competitive reversible antagonist. Used to control hypertension in pts w/ pheochromocytoma. Useful in treatment of hypertensive crisis that follow the abrupt withdrawl of clonidine or tyramine containg foods during the use of MAO inhibitors

Front 14

Prazosin(qunazolin)

Back 14

a1 receptor antag. lowers BP and therefore used for hypertension. reduces preload and afterload also good for conjestive heartfailure.

Front 15

Tamsulosin

Back 15

a agonist treat benign prostate hyperplasia.

Front 16

B-blockerse treat

Back 16

High BP, angina, irreg heart beat, migrane, prevent second heart attack, MI, tremors, Alcohol withdrwal, anxiety, glaucoma.

Front 17

Propranolol

Back 17

b receptor antagonist. little effect on CVS exert effects when sympathetic control is elevated as in exercise and stress.
results in decreased heart rate and CO.
exercise induced changes in cardiac parameters are blcoked i.s. exercise incread demands are reduced by bblockers useful in CAD.
peripheral resistance is increased and BP may increase until comp. decrease discharge to heart.
Blocks renin release.

Front 18

Labetolol

Back 18

1/3 as potent as propranolol. Ratio of b to a act is 3:1 orally and 7:1 iv. partial agonist good membrane stablizing. can blcok NET. lowers PVR w/ out major change in HR or CO.