Adrenergic Drugs

Front 1

Epinephrine
-Class
-Therapeutic use
-Adverse effects

Back 1

-Alpha beta agonists (all; b>a)
-anaphylaxis, angioedema, topical on surgical wounds (vasoconstriction), open angle glaucoma, CPR (asystole)
-CNS: anxiety, hemorrhage; HTN, palpitations, pulmonary edema {CONTRA: DM, HTN, heart dz, shock, hyperthyroidism, angina}

Front 2

Norepinephrine
-Class
-Therapeutic use
-Adverse effects

Back 2

-Alpha beta agonists (a1, a2>b1)
-hypotension + vasodilatory shock (spinal trauma, anesthesia, sepsis), given w/ local anesthesia to retard absorption
-similar to epi (less pronounced), necrosis/sloughing can occur at site of IV or IM injection

Front 3

Phenylephrine
-Class
-Therapeutic use
-Adverse effects

Back 3

-alpha agonist (a1)
-postural hypotension, nasal decongestants, mydriatics, local vasoconstriction (epistaxis)
-HTN, anginal pain, rebound congestion, photophobia {CONTRA: HTN, cardiac dz, hyperthyroidism, urinary retention}

Front 4

Clonidine
-Class
-Therapeutic use
-Adverse effects

Back 4

-alpha agonist (a2)= 100% oral bioavailability
-HTN (2nd choice), drug withdrawal, preanesthetic meds, neuropathic pain, menopausal hot flashes, neuropsychiatric disorders
-sedation, dec REM sleep, nightmares, HTN crisis (when w/drawn),xerostomia, constipation, sex dysfunction, skin eruptions (transdermally)

Front 5

Apraclonidine
-Class
-Therapeutic use
-Adverse effects

Back 5

-alpha agonist (a2)
-Open angle glaucoma

Front 6

Isoproterenol
-Class
-Therapeutic use
-Adverse effects

Back 6

-Beta agonist (b1,2,3)
-emergency situation when HR is slow and TPR is high (after heart sx), polymorphic ventricular tachycardia, B-blocker OD

Front 7

Dobutamine
-Class
-Therapeutic use
-Adverse effects

Back 7

-Beta agonist (b1) - higher doses-b2, a1
-given only through IV for cardiac failure or cardiogenic shock with severely depressed L ventricular function

Front 8

Albuterol
-Class
-Therapeutic use
-Adverse effects

Back 8

-Beta agonist (b2)
-Asthma (1st choice for asthma attack), COPD, premature labor, hyperkalemia
-CNS tremors/convulsions, sinus tachycardia, angina, hypoxemia (bc of pulmonary dilation), pulmonary edema, hypokalemia, hyperglycemia {CONTRA: cardiac arrythmias, coronary heart dz, hyperthyroidism, pheochromocytoma, seizure history, DM, elderly (more prone to tremors and tachy)}

Front 9

Salmeterol
-Class
-Therapeutic use
-Adverse effects

Back 9

-Beta agonist (b2)- long acting, (aerosol)

Front 10

Dopamine
-Class
-Therapeutic use
-Adverse effects

Back 10

-D-receptor agonist (d1,2) (b1 + a1 with high doses)
-cardiogenic, neurogenic, and septic shock (when there is poor renal perfusion)
-highly variable response

Front 11

Methyldopa
-Class
-Therapeutic use
-Adverse effects

Back 11

-Mixed acting (mainly indirect)
-gets transformed into methylNE an a2 agonist - reduces central adrenergic tone

Front 12

Tryamine
-Class
-Therapeutic use
-Adverse effects

Back 12

-Mixed acting (mainly indirect)
-localize sympathetic nerve lesion
-if administered with an MAO inhibitor can cause symp actions (potentially lethal HTN crisis- too much NE release)

Front 13

Cocaine
-Class
-Therapeutic use
-Adverse effects

Back 13

-Mixed acting (mainly indirect)
-block catecholamine re uptake in CNS and PNS

Front 14

Amphetamine
-Class
-Therapeutic use
-Adverse effects

Back 14

-mixed acting (mainly indirect)
-stimulates release of NE, DA, and serotonin- mood elevators, ability to con'c= ADHD,narcolepsy, weight reduction
-OD, agitation, hyperthermia, seizures