Adrenergic Antagonists

Front 1

blockade of alpha receptors in smooth muscle

Back 1

results in
-reduced peripheral resistance and BP

Front 2

alpha antagonist given with epinephrine:

Back 2

epinephrine reversal in which a1 vasoconstriction is blocked and B2 vasodilation is unopposed

fall in resistance and BP instead of inc of BP normally seen.

Front 3

a antagonists on heart

Back 3

inc in heart rate bc of:
-reflex in response to dec bc of alpha antagonist
-blockage of a2 presynaptic receptors which normally dec NE release

Front 4

a1 antagonists on veins

Back 4

orthostatic hypotension

Front 5

alpha antagonist list

Back 5

tamsulosin, prazosin, terazosin, doxazosin a1>>>a2

phenoxybenzamine a1>a2

Phentolamine a1=a2

rauwolscine, yohimbine, tolazoline a2>>>a1

Front 6

Phentolamine

Back 6

potent reversible competetive non selective alpha antagonist

manage hypertensive crisis (surgery for phaeochromocytoma)

net effect: inc C.O., vasodilation, no change in BP.

Front 7

Phenoxybenzamine

Back 7

irreversible a adrenergic receptor antagonist, a1>a2

Front 8

Prazosin
Doxazosin
Terazosin

Back 8

highly selective antagonist of a1 adrenoreceptors

relieve symptoms of urinary obstruction in benign prostatic hyperplasia and hypertension in raynaud's syndrome

Front 9

tamsulosin

Back 9

a1 selective antagonist-

higher selectivity for relieving urinary retention in benign prostatic hyperplasia

might be preferred if patient has experienced postural hypotension, but if patient has comorbid hypertension then use zosins

Front 10

yohimbine

Back 10

a2 selective adrenoceptor antagonist - no clinical use

Front 11

propanolol

Back 11

prototypical beta blocker
non selective agent

clinically for hypertension,
major effect of B-blockers is on heart to dec hypertension

Front 12

labetolol and carvedilol

Back 12

block a1 and B receptors

Front 13

In people who are normotensive, taking a beta agonist will result in

Back 13

nothing- reduces hr in hypertension- does not cause hypotension in normotensive people.

Front 14

Chronic use of B-blockers results in

Back 14

total resistance returning to initial values in presence of hypertension

delayed fall in peripheral resistance and persistent reduction of CO accounts for antihyypertensive action for these drugs

Front 15

beta blockers and CV system

Back 15

supraventricular arrhythmias and ventricular arrhytmias

acute M.I.

heart failure

angina (improves relationship of cardiac oxygen supply and demand)

Front 16

beta blockers and respiratory system

Back 16

propanolol block B2 receptors in the bronchial smooth muscle

-can lead to lethal bronchoconstriction in persons with asthma or COPD

Front 17

Beta blockers and metabolic effects

Back 17

B1 selective agents in patients with diabetes are preferable

B2 antagonist will block tachycardia (warning sign) and glycolysis and gluconeogenesis

Front 18

beta blockers and the eye

Back 18

dec in production of aq humor by pilocarpine and timolol for glaucoma

Front 19

carvedilol

Back 19

also a1 antagonist,

Front 20

labetalol

Back 20

nonselective b antagonist
a1 antagonist
b1 antagonist
partial agonist B2


can cause orthostatic hypertension

Front 21

partial agonist

Back 21

labetalol
penbutolol
pindolol
acebutalol (b1 selective)
celiprolol (b1 selective)

Front 22

nadolol

Back 22

non selective b blocker
longest acting

Front 23

timolol

Back 23

non selective b blocker

use with pilocarpine for open angle glaucoma

Front 24

penbutolol

Back 24

non selective b blocker

partial agonist

Front 25

pindolol

Back 25

non selective b blocker
partial agonist

Front 26

acebutolol

Back 26

b1 selective blocker, partial agonist,

Front 27

atenolol

Back 27

b1 selective blocker
longer hl then others in class

Front 28

celiprolol

Back 28

b1 selective partial agonist
b1 antagonist and b2 agonist

Front 29

esmolol

Back 29

b1 selective blocker, lasts 10 minutes
-used in critically ill patients sensitive to bradycardia

Front 30

metoprolol

Back 30

b1 selective blocker, widely used

Front 31

b-blocker and hyperthyroidism

Back 31

excessive catecholamine activity causes tachycardia and heart failure

b blockers can be used to control this

Front 32

b blocker and migraines

Back 32

can reduce frequency and intensity but do not prevent or stop when it has already started

Front 33

b blockers and cv adverse effect

Back 33

caution of use in people with CHF, can reverse adverse affects with isoproterenol

Front 34

indirect adrenergic receptor antagonists

Back 34

-blocks release of catecholamines
-reserpine- drop in BP and cardiac rate- effects persist for days
-guanethidine- drug blocks release of NE- gradual lowering of BP and HR
-Metyrosine