Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
23 Cards in this Set
- Front
- Back
|
alpha -1
|
post synaptic adrenoreceptors located in smooth muscle
activation increases intracellular calcium ion concentration little inotropic and negative chronotropic effects |
|
|
alpha-1
what does it do to the pupils? what does it do with insulin and lipds? |
mydriasis (pupil constriction)
inhibit secretion of insulin inhibits lipolysis |
|
|
alpha 2 location?
|
presynaptic nerve terminal
|
|
|
alpha -2
mechansim? |
decrease entry of calcium into the neuronal terminal limiting the release of norepinephrine
additionally vascular smooth muscle contain post-synaptic alpha2 receptors that produce vasoconstriction |
|
|
b2
|
bronchodilation
vasodilation relaxation of uterus bladder and uterus |
|
|
b3
|
gall bladder and in brain adipose tissue
|
|
|
chronotropy
|
HR
|
|
|
dromotropy
|
increased conduction
|
|
|
fenoldopam
|
DA1
|
|
|
dobutamine
|
nonspecific beta agonists
More B1 than B2 some or none Alpha 1 properties |
|
|
clonidine
|
alpha 2
negative chronotropic effects decrease catecholamine levels prolongs duration of block |
|
|
side effects of clonidine
|
bradycardia
hypotension sedation respiratory depresssion dry mouth |
|
|
dexmedetomidine
|
sedative
analgesic sympatholytic less significant respiratory depression side effects: hypotension and bradycardia |
|
|
long term use of alpha 2 agonists can lead to what if suddenly stopped
|
upregulation of receptors and supersensitization
acute withdrawal and hypertensive crisis |
|
|
epi
|
1mg/250ml = 4mcg/ml
infusion rate = 2-20mcg/min b1 b2 a1 a2 |
|
|
norepi
|
2mg/250 = 8mcg/ml
infusion rate = 2-20mcg/min b1, a1, a2 |
|
|
dopamine
|
<2mcg/kg/min
vasodilation the renal vasculature & diuresis 2-10mcg/kg/min b1 stimulation increases myocardial contractility, HR, cardiac output 10-20mcg/kg/min increase SVR and fall in renal blood >20mcg/kg/min release NE (indirect effects) |
|
|
isoproterenol
|
pure B-agonist
B1 increase HR contractility and cardiac output B2 decrease PVR and diastolic blood pressure increasing oxygen demand and while decreasing oxygen supply making it a poor ionotrope |
|
|
dobutamine
|
-relatively selective B1 agonist
-rise of cardiac output from increase contractility -slight decrease in PVR -left ventricular filling pressure decreases whereas coronary blood flow increases |
|
|
which drug is more favorable for CHF and CAD patients?
|
dobutamine
increase cardiac output while increasing coronary blood flow |
|
|
dobutamine packaging
|
1g/250ml
4mcg/ml |
|
|
infusion rates: epi, norepi, dopamine, dobutamine
|
2-20mcg/min, 2-20mc/min, 2-20mcg/kg/min, 2-20mcg/kg/min
|
|
|
dopexamine is an analogue of what?
and how is it better than that drug? |
analogue of dopamine
less B1 and alpha1 adrenergic effects specifies more on renal perfusion |
