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15 Cards in this Set
- Front
- Back
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What are Glucocorticoids?
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________increase the production of surfactant in the fetal lung and also help in the development of fetal lung.
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_____________ a glucocorticoid with a low degree of protein binding, is given to the pregnant women in premature labor to hasten maturation of the lungs.
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Dexamethasone
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________is abused by body builders and other steriod users to lower circulating levels of cortisol in the body and prevent muscle loss. Also, it is also an inhibitor of aromatase activity.
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Aminoglutethimide
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It may take ______months for the HPA axis to function properly after suppression.
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2-12
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Major adverse effects of _____________ are salt and water retention and hirsutism resulting from diversion of 11-deoxycortisol precursor to DOC and androgens
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Metyrapone
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What is Ketoconazole?
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It inhibits 17-20 lyase and side chain cleavage (SCC) enzymes required for the adrenal steroid synthesis.
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It is used in the treatment of breast cancer and cushing’s syndrome.
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Aminoglutethimide
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_________ inhibits both adrenal and gonadal steroid synthesis at high dose and it is a inhibitor of adrenal steroid synthesis at low dose.
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Ketoconazole
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What is Metyrapone?
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a selective inhibitor of glucocorticoid synthesis
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What is Eplerenone?
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It is an aldosterone antagonist used as an adjunct in the management of chronic heart failure.
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What is Mifepristone?
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Anti-progesterone activity by blocking the receptor. High doses exerts anti-glucocorticoid activity
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______ can be used for adrenal carcinoma and to induce early abortion.
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Mifepristone
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_______ competes with aldosterone binding site and decrease its effect and is used in the treatment of primary hyperaldosteronism
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Spironolactone
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_________is used in hypertension as it blocks aldosterone binding sites but has the advantage that it does not block androgen receptors.
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Eplerenone
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METAPYRONE CAUSE DISINHIBITION OF ACTH SECRETION BY ____________ AND CAN BE USED AS TEST OF ACTH RESERVE
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BLOCKING FEED BACK INHIBITION OF CORTISOL
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