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20 Cards in this Set
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- 3rd side (hint)
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Aminoglutethimide
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inhibits synthesis of adrenal steroids
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Anti-glucocorticoids (for hypercorticism) like for an adrenal tumor
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Fludrocortisone
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promotes reabsorption of sodium and enhanced secretion of potassium, used for replacement therapy
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Mineralocorticoids
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involved w/Na fluid balance
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(remember aldosterone)
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HOW ARE CORTICOSTEROIDS CLASSIFIED?
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classified as short, intermediate or long acting
Page 854 |
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HOW DO CORTICOSTERIODS DIFFER?
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IN POTENCY, ONSET & DURATION
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WHAT CLASSIFICATION OF DRUG IS PREDNISONE?
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INTERMEDIATE ACTING
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WHAT IS PREDNISONE USED FOR?
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replacement therapy (adrenal insufficiency
rheumatic disorders renal disease allergic disease asthma infectious disease skin disease GI disease hepatic disease |
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Pharmacologic Actions of Glucocorticoids?
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Anti-inflammatory action
Maintenance of normal blood pressure Carbohydrate and protein metabolism Fat metabolism Thymolytic, lympholytic, and eosinopenic actions Stress effects Central nervous system |
(see page 851-852)
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Methimazole
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inhibit incorporation of iodide during the process of T3/T4 synthesis
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Thioamide Derivitive
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Antithyroid Agents
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Levothyroxine: synthetic T3
Iodine: high concentrations decrease the synthesis of T3 and T4 Radioactive Iodide: particle emissions destroys tissue, used for hyperthyroidism |
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how were tyroid preparations initially derived?
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pigs & cow
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Bisphosphonates
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inhibit bone resorption, Paget's Disease (abnormal bone growth) used for hyperparathyroid hormone levels
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Paget's Disease
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Calcitonin
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remember important for calcium uptake to bone
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used to treat osteoporosis, hypercalcemia.
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Parathyroid
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remember PTH decreases body calcium
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what does the parthyroid decrease in the body?
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calcium
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Vasopressin
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aka ADH, used to treat diabetes insipidus, extreme polyuria, deficiency of ADH
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aks ADH
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Octreotide (Sandostatin)
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somatostatin analog, inhibits GH, used to treat GH excess
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Somatropin (various trade names)
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identical to GH, same indication
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Somatrem (Protropin)
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derivative of GH, used to treat GH deficiency
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what 4 types of cells does the islets of lanagerhans contain?
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islets of langerhans contain several types of cells:
alpha: secrete glucagon, stimulates production of glucose in the liver beta: secrete insulin, number of actions including uptake of glucose by various tissues delta: secrete somatostatin, reduce absorption of food gamma: peptide with unknown function |
JRA
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