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34 Cards in this Set

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What is the precursor for synthesis of corticoids?
cholesterol
Outline the synthesis of corticoids
1. adrenal cortical cells endocytose LDL via plasma membrane receptors
2.Cholesterol transfered to the mitochondria and converted to pregnenolone
3. pregnenolone move to ER
What are the 3 zones of the cortex?
1. Gromerulosas
2. Fascticulata
3. Reticularas
What is the innermost part of the adrenal gland?
Medulla
What does the adrenal medulla secrete?
circulating catecholamines, synthesized from tyrosine
What does the Zona Glumerulosa secrete?
Aldosterone, mineralocorticoid
What increases secretionof Aldosteron
Angiotensin II and potassium
What does the zona fasticulata secrete?
cortisol, glucocorticoid
What does the zona reticularis secrete
Androgenic hormones
2 androgenic hormones?
DHEA-S and androstenedione
What are the 2 life esential hormones?
aldosterone and cortison
What are 4 key fxns of cortisol?
1. metabolism/glucose
2. Vascular
3. CNS fxn
4. anti inflamatory
How is cortisol secreted?
hypothalamic (CRF) to
Ant. Pituitary (ATCH) to
Adrenal Gland (cortisol)
What else is secreted when ACTH is?
endorphins and MSH
What is preproopiomelanocortin?
the whole molecule that ACTH is a part of
Which zones does ATCH really effect?
fasticulata, reticularis
what decreases secretion of ATCH?
neg. feedback of cortisol
What stimulates secretion of ATCH?
fluxuates due to circadium rhythm
CRF
pysiological stree
What is transcortin?
The main tissue cortisol travels bound to
What is plasma cortisol in equilibrium w/?
cortisone, the biologically inactive analog
Why is the cortisol bound
to keep it in the solution and keep it cool
What does free cortisol do
1. Binds to the Glucocorticoid receptors
2. Moves into nuclues and binds to GREs
3. gene trasncription initiates/repressed
Which tissues have a lot of glucocorticoid receptors?
skeletal
What happens where there is too much cortical?
diminishes protein synthesis, degrades proteins (type 2b muscle fibers the most)
What are the 4 broad things cortisol effects?
metabolism, body tissues, inflamatory responses, immune response
Which zones does ATCH really effect?
fasticulata, reticularis
what decreases secretion of ATCH?
neg. feedback of cortisol
What stimulates secretion of ATCH?
fluxuates due to circadium rhythm
CRF
pysiological stree
What is transcortin?
The main tissue cortisol travels bound to
What is plasma cortisol in equilibrium w/?
cortisone, the biologically inactive analog
What are 2 things cortisol inibits?
bone formation and collagen synthesis
What are three things cortisol is necessary for?
fetal development, nervous system, blood pressure
What is cushing syndrome?
from too much cortisol, causing fragile skin and trunkal obessity
What does cortisol do to inflamatory/immune response?
supres