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34 Cards in this Set
- Front
- Back
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What is the precursor for synthesis of corticoids?
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cholesterol
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Outline the synthesis of corticoids
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1. adrenal cortical cells endocytose LDL via plasma membrane receptors
2.Cholesterol transfered to the mitochondria and converted to pregnenolone 3. pregnenolone move to ER |
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What are the 3 zones of the cortex?
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1. Gromerulosas
2. Fascticulata 3. Reticularas |
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What is the innermost part of the adrenal gland?
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Medulla
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What does the adrenal medulla secrete?
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circulating catecholamines, synthesized from tyrosine
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What does the Zona Glumerulosa secrete?
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Aldosterone, mineralocorticoid
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What increases secretionof Aldosteron
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Angiotensin II and potassium
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What does the zona fasticulata secrete?
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cortisol, glucocorticoid
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What does the zona reticularis secrete
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Androgenic hormones
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2 androgenic hormones?
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DHEA-S and androstenedione
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What are the 2 life esential hormones?
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aldosterone and cortison
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What are 4 key fxns of cortisol?
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1. metabolism/glucose
2. Vascular 3. CNS fxn 4. anti inflamatory |
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How is cortisol secreted?
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hypothalamic (CRF) to
Ant. Pituitary (ATCH) to Adrenal Gland (cortisol) |
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What else is secreted when ACTH is?
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endorphins and MSH
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What is preproopiomelanocortin?
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the whole molecule that ACTH is a part of
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Which zones does ATCH really effect?
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fasticulata, reticularis
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what decreases secretion of ATCH?
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neg. feedback of cortisol
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What stimulates secretion of ATCH?
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fluxuates due to circadium rhythm
CRF pysiological stree |
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What is transcortin?
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The main tissue cortisol travels bound to
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What is plasma cortisol in equilibrium w/?
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cortisone, the biologically inactive analog
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Why is the cortisol bound
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to keep it in the solution and keep it cool
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What does free cortisol do
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1. Binds to the Glucocorticoid receptors
2. Moves into nuclues and binds to GREs 3. gene trasncription initiates/repressed |
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Which tissues have a lot of glucocorticoid receptors?
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skeletal
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What happens where there is too much cortical?
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diminishes protein synthesis, degrades proteins (type 2b muscle fibers the most)
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What are the 4 broad things cortisol effects?
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metabolism, body tissues, inflamatory responses, immune response
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Which zones does ATCH really effect?
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fasticulata, reticularis
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what decreases secretion of ATCH?
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neg. feedback of cortisol
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What stimulates secretion of ATCH?
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fluxuates due to circadium rhythm
CRF pysiological stree |
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What is transcortin?
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The main tissue cortisol travels bound to
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What is plasma cortisol in equilibrium w/?
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cortisone, the biologically inactive analog
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What are 2 things cortisol inibits?
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bone formation and collagen synthesis
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What are three things cortisol is necessary for?
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fetal development, nervous system, blood pressure
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What is cushing syndrome?
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from too much cortisol, causing fragile skin and trunkal obessity
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What does cortisol do to inflamatory/immune response?
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supres
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