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4 Cards in this Set
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***Steroidogenic Inhibitors – Mitotate***
MOA, exact unknown |
Inhibition of steroid synthesis; Alteration of peripheral steroid metabolism; Inhibition of adrenal cortisol release
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***Steroidogenic Inhibitors – Mitotate***
Kinetics |
Slow onset of action – weeks… monitor free urine cortisol to guide therapy
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***Steroidogenic Inhibitors – Mitotate***
AE |
GI (N/D, anorexia); Neuromuscular (fatigue/weakness); CNS depression (somnolence, dizziness)
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***Steroidogenic Inhibitors – Mitotate***
Clinical use |
Medical adrenalectomy: if complete ablation of cortisol production is needed
Remission rates: 80% respond, 60% of these relapse with continued therapy; drug + radiation has 30% relapse |
