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16 Cards in this Set

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  • Back
what are the actions of aldosterone?
endogenous mineralocorticoid
responsible for Na retension, K excretion
decreased levels in hypoadrenocorticism can cause hyponatremia and hyperkalemia
Where is aldosterone produced?
zona glomerulosa of the adrenal gland
What is produced in the zona fasciculata and zona reticularis?
glucocorticoids
What must be done to treat hypoadrenocorticism?
supplement with mineralocorticoids and glucocorticoids
What glucocorticoids are used to treat hypoadrenocorticism?
prednisone, prednisolone
What drugs are used to replace mineralocorticoids in hypoadrenocorticism?
Desoxycorticosterone pivalate
Fludrocortisone acetate
What is hyperadrenocorticism?
overproduction of corticosteroids, especially cortisol
What are the symptoms of hyperadrenocorticism?
PU-PD, lethargy, pot belly, alopecia, muscle wasting
MOA of Trilostane
inhibits 3-beta-hydroxysteroid dehydrogenase
- blocks synthesis of adrenal steroids in adrenal gland by blocking formation of progesterone
What is the main contraindication for adrenal drugs?
don't use in pregnant or breeding animals, since sex steroid hormone levels are altered
Mitotane MOA
destroys the zona fasciculata and reticularis
-decreased glucocorticoid production
-little effect on aldosterone
Ketoconazole MOA
inhibits formation of cholesterol from lanosterol by blocking CYP450 enzymes
-cholesterol is the precursor for ALL steroid hormones
*can potentiate drugs that are metabolized by CYP450 enzymes
What drugs are used to treat both pituitary and adrenal causes of hyperadrenocorticism?
Trilostane
Mitotane
Ketoconazole
Selegiline MOA as a treatment for hyperadrenocorticism
monoamine oxidase B inhibitor
-increases dopamine levels, which decreases ACTH secretion and lowers cortisol production
*doesn't treat underlying disease, just symptoms
Pergolide MOA
dopamine agonist at D1 and D2 receptors
increased dopamine-like stimulation causes decreased ACTH, cortisol levels
*inhibits lactation because it has effects on prolactin
*must be compounded, because not available in any form in USA
What drugs are used to treat pituitary causes of hyperadrenocorticism?
selegiline
pergolide