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18 Cards in this Set
- Front
- Back
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adipocyte precursor cells
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mesenchymal stem cells
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signal mechanism of leptin
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JAK/STAT
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increases insulin sensitivity
increases glucose uptake in sk. muscle decreases plaque formation in vessels |
adiponectin
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increases glucose uptake in sk. muscle
satiety factor increases TRH |
leptin
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decreases glucose uptake in the liver
increases resistance to insulin |
resistin
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decreases adiponectin
decreases insulin receptors |
IL-6
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cleaves pro-forms of IL-1B and IL-18 to active forms
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caspase-1
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cytokines (cleaved by caspase-1) that cause the inflammatory state assx with obesity
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IL-1B and IL-18
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promotes neointimal growth (plaque development)
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plasminogen activator inhibitor-1 (PAI-1)
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which form of adipocyte growth causes a higher increased risk for diabetes/CVD
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hypertrophy (large adipocytes)
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GI hormone that increases appetite
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ghrelin
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how does removal of the stomach reduce food intake
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reduces ghrelin (orexigenic)
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how does interposition of the ileum lead to bariatric success
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slows gastric emptying
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nuclear hormone receptor important in adipocyte differentiation
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PPAR-gamma
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appetite suppressing neuronal pathway
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POMC
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appetite stimulating neuronal pathway
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neuropeptide Y
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why can leptin not be given for tx of obesity
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resistance
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decreases uptake/storage of glucose
increases degradation of IRS-1/2 (insulin receptor substrates) |
TNF-alpha
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