Adenosine

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ADENOSINE
Class/MOA

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Class
Endogenous Nucleotide
Mechanism of action
Slows conduction time through the AV Node; can interrupt re-entrant pathways; slows
heart rate; acts directly on sinus pacemaker cells. Is drug of choice for PSVT. Can be
used diagnostically for stable, wide-complex tachycardias of unknown type after two
doses of Lidocaine.

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ADENOSINE
I/CI

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Indications
Conversion of PSVT to sinus rhythm. May convert PSVT due to Wolff-Parkinson-
White syndrome.
Not effective converting atrial fibrillation / flutter.
Contraindications
Second or third-degree " block or Sick Sinus Syndrome
Atrial flutter / atrial fibrillation
Ventricular Tachycardia
Hypersensitivity to adenosine

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ADENOSINE
DI/AR

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Adverse Reactions
Facial flushing, shortness of breath, chest pain, headache, paresthesia, diaphoresis,
palpitations, hypotension, nausea, metallic taste.
Drug Interactions
Methylxanthines (theophylline-like drugs) antagonize the effects of adenosine.
Dipyridamole (Persantine) potentiates the effects of adenosine
Carbamazepine (Tegretol) may potentate the AV Node blocking effects of adenosine.
May cause bronchoconstriction in asthmatic patients.

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ADENOSINE
How supplied

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How Supplied
Three mg/ml in 2-ml flip-top vials for IV injection

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ADENOSINE
Dosages

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Dosage and Administration
Adult: 6 mg over 1-3 seconds; If no response after 1-2 minutes, administer 12 mg
over 1-3 seconds, Maximum total dose = 30 mgs.
Pediatric: 0.1 - 0.2 mg/kg rapid IV; maximum single dose = 12 mgs.

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ADENOSINE
DOA/Specials

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Duration of action
Onset and peak effects in seconds; duration 12 seconds.
Special Considerations
Short half-life limits side effects in most patients.
Pregnancy safety: Category C.