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9 Cards in this Set

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methadone
- heroine detox (mu-opioid agonist, longer half life, less withdrawal)
preventing relapse - prevents rapid on-off reward, allows for cross tolerance to take place
clonidine
heroine detox - helps inhibit NE through A2 receptor (NE stimulates symptoms)
naltrexone
- heroine detox (used with general anesthetic)
preventing relapse - mu-opioid antagonist (30 day administration)
(used in both alcohol and heroine, stops reward system)
nicotine replacement
allows for steady state of nicotine, so no withdrawals
-problems: nicotine is not only addictive substance
buproprion
inhibits uptake of Monoamines,after tobacco withdrawal.
therefore leveling out dopamine after withdrawal (stops craving)
varenicline
nicotinic partial agonist with higher affinity for receptor. increases dopamine levels, but not as much.
higher rate of abstinence (22%)
diazepam
long lasting sedative used for alcohol detox, should be tapered slowly
acts on the gaba system
disulfuram
blocks acetaldehyde dehydrogenase (causes ill side effects of alcohol). (aversion therapy)
acamporsate
blocks glutamate receptor, blocking reward system from relying heavily on glutamate.