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9 Cards in this Set
- Front
- Back
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methadone
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- heroine detox (mu-opioid agonist, longer half life, less withdrawal)
preventing relapse - prevents rapid on-off reward, allows for cross tolerance to take place |
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clonidine
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heroine detox - helps inhibit NE through A2 receptor (NE stimulates symptoms)
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naltrexone
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- heroine detox (used with general anesthetic)
preventing relapse - mu-opioid antagonist (30 day administration) (used in both alcohol and heroine, stops reward system) |
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nicotine replacement
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allows for steady state of nicotine, so no withdrawals
-problems: nicotine is not only addictive substance |
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buproprion
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inhibits uptake of Monoamines,after tobacco withdrawal.
therefore leveling out dopamine after withdrawal (stops craving) |
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varenicline
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nicotinic partial agonist with higher affinity for receptor. increases dopamine levels, but not as much.
higher rate of abstinence (22%) |
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diazepam
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long lasting sedative used for alcohol detox, should be tapered slowly
acts on the gaba system |
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disulfuram
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blocks acetaldehyde dehydrogenase (causes ill side effects of alcohol). (aversion therapy)
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acamporsate
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blocks glutamate receptor, blocking reward system from relying heavily on glutamate.
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