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13 Cards in this Set
- Front
- Back
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What are the 5 hallmarks of acute inflammation?
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Swelling
Redness Heat Pain Loss of function |
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What cells are the first to infiltrate tissue in acute inflammation?
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Neutrophils
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What mediates tight adhesion between leukocytes and endotheliu?
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Endothelial ICAm and Intergrins on leukocytes
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What mediates slowing of neutrophils on endothelium?
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Exposure to inflammatory mediators cause expression of P selectin and E selectin which binds to SLeX carbohydrate
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Name the two mechanisms proposed for phagocytosis:
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Zipper & Trigger
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Name 3 opsonins:
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1. IgG antigen complex
2. C3b 3. Surfactant proteins A & D 4. C reactive protein |
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Name three pattern recognition receptors on macrophages:
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Toll Like Receptors
Scavenger Receptor Mannose Binding Lectin |
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What complement component is key in attraction of neutrophils?
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C5a
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What complement component is important in opsonisation.
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C3b (and C4b)
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What complement component initiates the Membrane Attack Complex?
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C5b
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How is the classical complement pathway triggered?
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Activation of C1 complex when C1q binds to IgM or IgG complexed with antigen, OR when C1q binds to the surface of a pathogen.
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How is the alternative complement pathway triggered?
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Spontaneous C3 hydrolysis on the surface of a pathogen
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How is the lectin complement pathway triggered?
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By binding of mannose-binding lectin to mannose residues on the pathogen surface (activating MBL associated serine proteases which split C4 into C4a & b and split C2 into C2a and C2b
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