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13 Cards in this Set
- Front
- Back
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What are the three determinants of MVO2
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-heart rate
-wall stress (preload & afterload) -contractility |
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What are the determinants of O2 supply
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-coronary blood flow
-oxygen extraction |
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What are the categories of anti-anginal agents
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nitrovasodilators
b-adrenergic blockers calcium channel blockers other (aspirin, heparin) |
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What are the two main MOA of nitrovasodilators
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-reduce O2 demand
-increase O2 supply --relax large arteries, relax veins, inhibit platelet aggregation |
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nitroglycerin is a
-metabolism -duration |
-nitrovasodilator
-first pass hepatic metabolism -dependent on formulation |
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isosorbide dinitrate (ISDN)
-duraction -administration |
-nitrovasodilator
-3-5 hours -3-4x daily |
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Isosorbide mononitrate (ISMN)
-duration -metabolism |
-nitrovasodilator
-longer duration of action -minimal first pass metabolism |
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Sildenafil, tadalafil, vardenafil
-do what -affect BP how |
-phosphodiesterase 5 inhibitors
-increase levels of cGMP -modest drop in BP, combo w/nitrates can cause hypotension though |
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verapamil
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-calcium channel blocker
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diltiazem
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calcium channel blocker
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nifedipine, amodipine, felodipine, nicardipine, nimodipine
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-dihydropyridines (calcium channel blockers)
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ranolazine
-MOA |
-antianginal drug
-unclear, inhibitor of late sodium current resulting in a reduction of the intracellular sodium and calcium overload in ischemic myocytes |
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clopidogrel
-MOA |
-thienopyridine
-prevents platelet aggregation by irreversibly binding ADP antagonist at P2 receptors |
