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15 Cards in this Set
- Front
- Back
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associated with metabolic acidosis and respiratory alkalosis
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salicylate overdose
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treatment of salicylate overdose
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activated charcoal and alkaline diuresis with extra KCl
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impair cellular respiration by uncoupling oxidative phosphorylation and stimulate respiratory centers in the medulla
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salicylates
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when does excretion of salicylates increase
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when urine pH increases
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what drugs should be avoided in patients with salicylate poisoning
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drugs that decrease respiratory drive
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binds to the Fe3+ form of cytochrome a in complex IV and blocks electron transport
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cyanide
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prehospital care of patient with cyanide poisoning
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airway management with 100%
administration of fluids and vasopressors administration of sodium bicarbonate |
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treatment of patient with cyanide poisoning
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administration of hydroxocobalamin, nitrites, and sodium thiosulfate
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what does hydroxocobalamin do in cyanide poisoning
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combines with cyanide to form cyanocobalamin and is cleared in the urine
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what does nitrites do in cyanide poisoning
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induce methemoglobin in RBCs which combine with cyanide and release it from cytochrome oxidase enzyme
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what should be avoided in patient with cyanide and CO poisoning
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sodium nitrite because presence of both carboxyhemoglobin and methemoglobin may significantly reduce oxygen-carrying capacity of blood
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what is hyperthermia assocaited with
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salicylate toxicity
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what increase salicylate concentration in the CNS - thus compounding its toxicity
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late metabolic acidosis
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what is consistently seen throughout acid-base states seen after an overdose of salicylates
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hypokalemia
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why does cyanide poisoning cause red venous blood
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binds to ferric heme blocking cellular O2 use which raises venous blood pO2
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