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15 Cards in this Set
- Front
- Back
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Which cation is required as a cofactor?
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Magnesium, for enzymatic reactions including phosphorylation of glucose within cells and the use of ATP
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The skeletal apparatus contains app how much PO4
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It has app 740g of PO4
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What is the PO4 conc of the plasma?
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1.8-2.6 meql
Po4 ion reabsorption along the PCT is stimulated by calcitriol |
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What is the most abundant anion in ECF?
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Cl- Plasma conc ranges from 100-108 meq/l
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The body contains 3 general categories of acids. What are they?
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Volatile acids
fixed acids organic acids |
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What happens when Co2 reacts with H2O?
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Carbonic acid is formed, which will eventually dissociate into H+ and HCO3 ions
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What is the difference between a fixed and a volatile acid?
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Fixed acids do not leave sol'n. Volatile acids do leave sol'n.
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What are the two most important fixed acids?
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H2SO4 and H2PO4. Created from AA metabolism
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Name an organic acid for this category?
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Lactic acid- from anaerobic metabolism of pyruvate and ketone bodies synthesized from Acetyl-CoA
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What do protein buffers depend on?
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On the ability of AA to respond to pH changes by accepting ot releasing H+ ions.
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If pH climbs, how does the carboxl group respond?
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The COOH group of the AA can dissociate acting as a weak acid by releasing a H+ ion
If pH goes down, it will accept a H+ ion. |
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How does the hemoglobin buffer system work?
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RBC s and their cytoplasm have large amounts carbonic anhydrase. They absorb CO2 from the plasma and convert it to H2CO3.
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What is the chloride shift?
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As the H2CO3 dissociates, the HCO3 ions diffuse into the plasma in exchange for Cl ions. H+ ions are buffered by hemoglobin molecules
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What is a respiratory acid base disorder?
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It is a mismatch between CO2 generation in peripheral tissues, and CO2 excretion at the lungs. CO2 at ECF level is abnormal.
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What is respiratory acidosis?
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The resp system cannot eliminate all the CO2 generated by peripheral tissues. Low pH is hypercapnia.
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