Acetylsalicylic Acid (Asa Asprin)

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Classification

Back 1

Analgesic, Antipyretic, Platelet Aggregate Inhibitor, NSAID

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Mechanism of Action

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1. Inhibits aggregation (clumping) of Platelets by blocking the formation of the substance thromboxne (A2) ; Prolonging bleeding time
2. Provides analgesia by inhibiting prostaglandins and other substances the sensitize pain receptors (Blocking of Prostaglandins also account for the drugs anti inflammatory effects)
3. Relieves fever by acting upon the hypothalamic heat regulating Center

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Indications

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1. Acute Myocardial infraction
2. Thrombotic Stroke

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Contraindications

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1. Active gastrointestinal bleeding
2. Asthma patients with nasal polyps (anaphylaxis is common)

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Side Effects

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GASTROINTESTINAL, Bleeding, heart burn, epigastric pain
CNS, Dizziness, confusion, drowsiness
ENT Tinnitus, hearing loss,
OTHER, May impair renal function, may prolong labor in pregnancy with increased bleeding

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Precautions

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1. Medical history of Pre-existing ulcers, liver disease or bleeding disorders
2. Due to the possible association of aspirin with Reye's syndrome, do not give drug to children or teenagers with signs and symptoms of chickenpox (varicella) without physician consultation

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Interactions

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1. inhibits Anti-hypertensive effects of ACE inhibitors
2. Ammonium chloride and other unripe acidifying drugs will increase effects of aspirin- watch for toxicity

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Routes of administration

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PO

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Onset and Duration of Actions

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On set 5-30 minutes and may last 1-4 hours, peak in 15 mins

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Dosages

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Adult: 162-325 mg PO
Pediatric: Not recommended