Ace Inhibitors

Front 1

What is renin and where is it stored?

Back 1

-protease
-renal juxtaglomerular apparatus

Front 2

What is angiotensinogen and where is it found?

Back 2

--plasma glycoprotein made in many organs

--only known substrate of renin, cleaved to make Ang I

Front 3

Ang I

Back 3

--decapeptide
--weak vasoconstrictor activity

Front 4

Ang II

Back 4

--potent vasoconstrictor

--made by proteolysis of Ang I by ACE

Front 5

Ang III

Back 5

--heptapeptide made by cleaving Ang II

-- <vasoconstrictor activity than Ang II

Front 6

bradykinin

Back 6

--potent vasodilator activity

--substrate for ACE which inactivates

Front 7

4 sites for regulation of renin secretion

Back 7

1) renal vascular stretch recptr

2) macula densa: dec. Na = inc. renin

3) SNS: B recptrs on juxtaglomerular cells

4) ang II: neg fdbk on jxg cells

Front 8

4 actions of ang II

Back 8

1) strong pressor response (resets baroceptors--no bradycardia)
2) stimulates aldosterone synth & release
3) stimulates thirst
4) mitogen for cardiac and vascular cells

Front 9

aliskiren

Back 9

orally active, non-peptide direct renin inhibitor

not a first line therapy

Front 10

3 classes of ACE inhibitors

Back 10

I: active drug, some active metabolites (catopril)

II: prodrugs activated in liver (all except catoril and lisinoril)

III: water soluble, active, excreted unchanged by kidney (liinopril)

Front 11

-sartin

Back 11

ATI antagonists

--fewer side effects than ACE inhibitors

--don't affect bradykinin levels