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43 Cards in this Set
- Front
- Back
How many Ig constant regions are in the heavy chain of IgG?
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3
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How many Ig constant regions are in the heavy chain of IgA?
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3
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How many Ig constant regions are in the heavy chain of IgM?
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4
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How many Ig constant regions are in the heavy chain of IgD?
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3
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How many Ig constant regions are in the heavy chain of IgE?
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4
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To what Ig region does omalizumab bind?
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C-epsilon-3
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On what chromosome is the kappa light chain encoded?
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2
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On what chromosome is the lambda light chain encoded?
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22
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How many fragments are generated with papain digestion of IgG?
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3 (2 binding regions and 1 constant region)
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How many fragments are generated with pepsin digestion of IgG?
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2 (1 binding region with 2 separate binding sites and 1 constant region)
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Which Ig class can circulate as dimers?
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IgA
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Which Ig class can circulate as pentamers?
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IgM
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A numerically higher Kd indicates lower or higher affinity?
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lower
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Which Ig class is the first produced after birth and the first to reach adult level?
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IgM
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Which Ig class(es) cross the placenta?
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IgG only.
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Which Ig class has the highest plasma concentration?
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IgG
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Which Ig class has the highest total body concentration?
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IgA
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What protein is responsible for transporting IgA across the mucosal epithelium?
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poly-Ig receptor
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What Ig class is the most efficient at fixing complement?
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IgM
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What IgG subclass has the shortest half-life?
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IgG3
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What is rheumatoid factor?
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Antibody against the Fc portion of immunoglobulin.
(Usually IgM, but can be any other isotype) |
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Which 2 IgG subclasses are most effective at fixing complement?
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IgG1 and IgG3
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Which IgG subclass is best for antibody dependent cell mediated cytotoxicity?
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IgG1
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Which IgA subclass is primarily in the respiratory tract?
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IgA1
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Which IgA subclass is primarily in the lower GI tract?
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IgA2
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Which Ig classes can fix complement?
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IgG and IgM
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Which IgG subclass is associated with a Th1 response?
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IgG1
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Which IgG subclass is assocaited with a Th2 response?
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IgG4
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Which IgG subclass is least efficiently transported across the placenta?
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IgG2
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Which 2 IgG subclasses are associated with protection against polysaccharides?
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IgG2 & IgG4
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2 cytokines characteristically associated with class switching to IgG1
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IFN-gamma
IL-4 |
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2 cytokines characteristically associated with class switching to IgG2
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IFN-gamma
TGF-beta |
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1 cytokine characteristically associated with class switching to IgG3
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IFN-gamma
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2 cytokines characteristically associated with class switching to IgG4
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IL-4
IL-13 |
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2 cytokines characteristically associated with class switching to IgA
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TGF-beta
IL-5 |
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2 cytokines characteristically associated with class switching to IgE
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IL-4
IL-13 |
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What feature of Ig development is the most responsbile for variability?
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Junctional diversity (random, non-templated, addition or removal of nucleotide sequences at V/D/J junctions.
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What functional feature of Ig development is the most responsbile for fine-tuning antibody affinity?
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Somatic hypermutation (point mutations in V regions of rapidly dividing B lymphocytes and selective survival of b lymphocytes that produce high affinity antibodies)
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What is CD64, where is it expressed, and what is its function?
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Fc-gamma-RI (high affinity IgG receptor)
Macrophages, neutrophils, eosinophils. Phagocytosis |
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What is CD32, where is it expressed, and what is its function?
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Fc-gamma-RIIA. (Also can be Fc-gamma-RIIB.)
Macrophages, neutrophils, eosinophils, platelets. (B-cells.) Low affinity IgG receptor; phagocytosis (poor); (Feedback inhibition of B-cells.) |
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What is CD16, where is it expressed, and what is its role?
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Fc-gamma-RIIIA (or Fc-gamma-RIIIB)
NK cells (neutrophils) Low affinity IgG receptor responsible for antibody dependent cell mediated cytotoxicity (phagocytosis, poor) |
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What is Fc-epsilon-RI, where is it expressed, and what is its role?
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High affinitiy receptor for IgE
Mast cells, basophils, eos Degranulation, antibody-dependent cell mediated cytotoxicity |
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What is CD23, where is it expressed, and what is its role?
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Fc-epsilon-RII (low affinitiy IgE receptor)
Neutrophils, eosinophils, monocytes Unknown function |