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24 Cards in this Set
- Front
- Back
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26. Which Quinolone(s) cover(s) gram positive the best?
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Gatifloxacin
Gemifloxacin Moxifloxacin |
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27. Which Quinolone has a caution for diabetics?
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(Pharmacopoeia)
Gatifloxacin- should monitor glucose closely; expect hypoglycemia in the first 2 days of therapy and hyperglycemia after 3rd |
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28. Which Quinolones cover anaerobes?
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Respiratory quinolones: Gatifloxacin, Moxifloxacin, Levofloxacin
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. Name the “cautions” associated with Quinolones as a class.
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altered cardiac conduction: Prolonged QTc interval
- CNS stimulation: tremors, restlessness, confusion - Crystalluria - Peripheral neuropathy - phototoxicity - tendon inflammation/ rupture - hypersensitivity |
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. Are quinolones inhibitors or inducers, if so which CYP?
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Ciprofloxacin inhibitor CYP 1A2 (strong) CYP3A4 (weak)
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Give general coverage macrolide
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Gram positive, gram negatives, anaerobes, atypicals
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. Do macrolides cover atypicals?
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Yes
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Does erythromycin cover H. flu?
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(30-60%) susceptible
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Give the general coverage of TCN
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sensitive gram positive and gram negative
mycoplasma, chlamydia, Richettsia, H. pylori |
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. Does minocycline cover MRSA
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30-60% susceptible
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Bactrim: which bugs does it cover? Does it include Pseudomonas
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E coli, Klebsiella, Enterobacter, P vulgaris, H flu, S pneumonia,
No it does not cover Pseudomonas |
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Name some strengths of using Bactrim.
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distrubtes well into tissue oral absorption close IV
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38. How would you dose Bactrim?
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Mild to moderate: oral 8-12mg TMP/kg/day divided doses q12h
Serious: oral 20mg TMP/kg/day divided doses q6h IV: 8-12mg TMP/kg/day q6h |
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39. Give the spectrum of aminoglycoside
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gram negative: Pseudomonas, Proteus, Serratia, H. flu, Salmonella, M.
cat gram positive: Staphylococcus (MSSA) |
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40. What is/are the IV compatibilities of Septra
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compatible with D5W
do not use normal saline |
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Which aminoglycoside covers Pseudomonas the best?
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Gentamicin
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Why are aminoglycosides used synergistically?
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Aminoglycosides are used along with a beta lactam antibiotics
(penicillins, cephalosporins, carbapenem) as a synergistic killing model. They are used together to reduce resistance and increase killing. |
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43. What do we monitor when a patient is on an aminoglycoside?
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Urine analysis
Urine output BUN Scr Peaks and troughs Hearing tests (to monitor for ototoxicity) |
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Give the spectrum for Flagyl
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covers anaerobes: B frag, P. melaninogenica, C. Diff, Clostridium,
peptrostreptococcus |
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what infections is/are Flagyl the drug of choice?
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c diff
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Dose Flagyl cover parasites? (what s the dose)?
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Yes amebiasis: oral 35-50mg/kg/day divided doses q8h x10d
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47. Does Flagyl cover Trichomonas (What is the dose)
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Yes, oral 15-30 mg/kg/day divided doses q8h x 7 d
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48. Give the coverage of zyvox
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Chalmydophilia, Clostridium (no c. diff) Peptostreptococcus,
Gram positive: staph epi, strep ABCG, Enterococcus faecalis, enterococcus, faecium, C. jeikeium, L. monocytogens |
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49. Give the conversion of zyvox from IV to PO
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600mg IV q12h to 600mg PO q12h
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