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24 Cards in this Set

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26. Which Quinolone(s) cover(s) gram positive the best?
Gatifloxacin
Gemifloxacin
Moxifloxacin
27. Which Quinolone has a caution for diabetics?
(Pharmacopoeia)
Gatifloxacin- should monitor glucose closely; expect hypoglycemia in the first 2 days of therapy and hyperglycemia after 3rd
28. Which Quinolones cover anaerobes?
Respiratory quinolones: Gatifloxacin, Moxifloxacin, Levofloxacin
. Name the “cautions” associated with Quinolones as a class.
altered cardiac conduction: Prolonged QTc interval
- CNS stimulation: tremors, restlessness, confusion
- Crystalluria
- Peripheral neuropathy
- phototoxicity
- tendon inflammation/ rupture
- hypersensitivity
. Are quinolones inhibitors or inducers, if so which CYP?
Ciprofloxacin inhibitor CYP 1A2 (strong) CYP3A4 (weak)
Give general coverage macrolide
Gram positive, gram negatives, anaerobes, atypicals
. Do macrolides cover atypicals?
Yes
Does erythromycin cover H. flu?
(30-60%) susceptible
Give the general coverage of TCN
sensitive gram positive and gram negative
mycoplasma, chlamydia, Richettsia, H. pylori
. Does minocycline cover MRSA
30-60% susceptible
Bactrim: which bugs does it cover? Does it include Pseudomonas
E coli, Klebsiella, Enterobacter, P vulgaris, H flu, S pneumonia,
No it does not cover Pseudomonas
Name some strengths of using Bactrim.
distrubtes well into tissue oral absorption close IV
38. How would you dose Bactrim?
Mild to moderate: oral 8-12mg TMP/kg/day divided doses q12h
Serious: oral 20mg TMP/kg/day divided doses q6h
IV: 8-12mg TMP/kg/day q6h
39. Give the spectrum of aminoglycoside
gram negative: Pseudomonas, Proteus, Serratia, H. flu, Salmonella, M.
cat
gram positive: Staphylococcus (MSSA)
40. What is/are the IV compatibilities of Septra
compatible with D5W
do not use normal saline
Which aminoglycoside covers Pseudomonas the best?
Gentamicin
Why are aminoglycosides used synergistically?
Aminoglycosides are used along with a beta lactam antibiotics
(penicillins, cephalosporins, carbapenem) as a synergistic killing
model. They are used together to reduce resistance and increase killing.
43. What do we monitor when a patient is on an aminoglycoside?
Urine analysis
Urine output
BUN
Scr
Peaks and troughs
Hearing tests (to monitor for ototoxicity)
Give the spectrum for Flagyl
covers anaerobes: B frag, P. melaninogenica, C. Diff, Clostridium,
peptrostreptococcus
what infections is/are Flagyl the drug of choice?
c diff
Dose Flagyl cover parasites? (what s the dose)?
Yes amebiasis: oral 35-50mg/kg/day divided doses q8h x10d
47. Does Flagyl cover Trichomonas (What is the dose)
Yes, oral 15-30 mg/kg/day divided doses q8h x 7 d
48. Give the coverage of zyvox
Chalmydophilia, Clostridium (no c. diff) Peptostreptococcus,
Gram positive: staph epi, strep ABCG, Enterococcus faecalis,
enterococcus, faecium, C. jeikeium, L. monocytogens
49. Give the conversion of zyvox from IV to PO
600mg IV q12h to 600mg PO q12h