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24 Cards in this Set

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  • Back
26. Which Quinolone(s) cover(s) gram positive the best?
27. Which Quinolone has a caution for diabetics?
Gatifloxacin- should monitor glucose closely; expect hypoglycemia in the first 2 days of therapy and hyperglycemia after 3rd
28. Which Quinolones cover anaerobes?
Respiratory quinolones: Gatifloxacin, Moxifloxacin, Levofloxacin
. Name the “cautions” associated with Quinolones as a class.
altered cardiac conduction: Prolonged QTc interval
- CNS stimulation: tremors, restlessness, confusion
- Crystalluria
- Peripheral neuropathy
- phototoxicity
- tendon inflammation/ rupture
- hypersensitivity
. Are quinolones inhibitors or inducers, if so which CYP?
Ciprofloxacin inhibitor CYP 1A2 (strong) CYP3A4 (weak)
Give general coverage macrolide
Gram positive, gram negatives, anaerobes, atypicals
. Do macrolides cover atypicals?
Does erythromycin cover H. flu?
(30-60%) susceptible
Give the general coverage of TCN
sensitive gram positive and gram negative
mycoplasma, chlamydia, Richettsia, H. pylori
. Does minocycline cover MRSA
30-60% susceptible
Bactrim: which bugs does it cover? Does it include Pseudomonas
E coli, Klebsiella, Enterobacter, P vulgaris, H flu, S pneumonia,
No it does not cover Pseudomonas
Name some strengths of using Bactrim.
distrubtes well into tissue oral absorption close IV
38. How would you dose Bactrim?
Mild to moderate: oral 8-12mg TMP/kg/day divided doses q12h
Serious: oral 20mg TMP/kg/day divided doses q6h
IV: 8-12mg TMP/kg/day q6h
39. Give the spectrum of aminoglycoside
gram negative: Pseudomonas, Proteus, Serratia, H. flu, Salmonella, M.
gram positive: Staphylococcus (MSSA)
40. What is/are the IV compatibilities of Septra
compatible with D5W
do not use normal saline
Which aminoglycoside covers Pseudomonas the best?
Why are aminoglycosides used synergistically?
Aminoglycosides are used along with a beta lactam antibiotics
(penicillins, cephalosporins, carbapenem) as a synergistic killing
model. They are used together to reduce resistance and increase killing.
43. What do we monitor when a patient is on an aminoglycoside?
Urine analysis
Urine output
Peaks and troughs
Hearing tests (to monitor for ototoxicity)
Give the spectrum for Flagyl
covers anaerobes: B frag, P. melaninogenica, C. Diff, Clostridium,
what infections is/are Flagyl the drug of choice?
c diff
Dose Flagyl cover parasites? (what s the dose)?
Yes amebiasis: oral 35-50mg/kg/day divided doses q8h x10d
47. Does Flagyl cover Trichomonas (What is the dose)
Yes, oral 15-30 mg/kg/day divided doses q8h x 7 d
48. Give the coverage of zyvox
Chalmydophilia, Clostridium (no c. diff) Peptostreptococcus,
Gram positive: staph epi, strep ABCG, Enterococcus faecalis,
enterococcus, faecium, C. jeikeium, L. monocytogens
49. Give the conversion of zyvox from IV to PO
600mg IV q12h to 600mg PO q12h