Abx I: Target Cell Wall

Front 1

Drugs that is Time-dependent killing? (BCVM)

Back 1

Beta-lactams
Clindamycin
Vancomycin
Macrolides

Front 2

Drugs that is concentration-dependent killing? (ADME-F)

Back 2

Aminoglycosides
Daptomycin
Metronidazole
Fluoroquinolones (FQ)

Front 3

Situations when cidal drugs are better?

Back 3

meningitis
endocarditis
G(-) bacteremia in neutropenia

Front 4

6 bacteriostatic drugs, the rest are all cidal. Name them? (4 drugs+2 classes)

Back 4

Bactrim (Trimethoprim-Sulfamethoxasole)
Clindamycin
Linezolid
Chloramphenicol
Tetracyclines
Macrolides

Front 5

Abx targets at cell wall? (BVD)

Back 5

B-lactam abx
Vancomycin
Daptomycin

Front 6

B-lactam abx inhibit cell wall synthesis by?

Back 6

Binding to PBP (PCN binding protein) which prevent it from cross-linking glycine bridge

Front 7

4 generations of penicillins?

Back 7

1. Natural pcn
2. Anti-staphyl pcn
3. Amino pcn
4. Ext. pcn

Front 8

Natural PCN does not cover__?

Back 8

Staph

Front 9

Natural PCN is the DOC for __?

Back 9

Syphilis

Front 10

Brand name of PCN G Benzathine?

Back 10

Bicillin L-A

Front 11

DOC for MSSA?

Back 11

Anti-Staph PCN
--Does not tx MRSA

Front 12

Name 3 drugs in anti-Staph PCN and it's route?

Back 12

Nafcillin, Oxacillin (IV/IM)
Dicloxacillin (PO)

Front 13

DOC for prophylaxis for bacterial endocarditis?

Back 13

Amino PCN

Front 14

Brand name of Ampicillin+Sulbactam and route?

Back 14

Unasyn (ampicillin+sulbactam)
(IV/IM)

Front 15

Brand name of amoxicillin + clavulanate is ____ /route?

Back 15

Augmentin (amoxicillin+clavulanate) PO

Front 16

TWO classes of PCN that required renal adjust?

Back 16

Natural PCN
Ext. PCN

Front 17

ONE classes of PCN that does NOT required renal adjust?

Back 17

Anti-staph PCN

Front 18

The ONLY class of PCN that covers pseudomonas?

Back 18

Ext. PCN

Front 19

Names two drugs in Ext. PCN and brand name?

Back 19

Pipracillin-Tazobactam (Zosyn)
Ticarcillin-clavulanate (Timentin)

Front 20

Zosyn v.s. Timentin, which one has better coverage of pseudomonas?

Back 20

Zosyn

Front 21

No cephalosporin covers this class of bug?

Back 21

Enterococcus

Front 22

Brand name of cefazolin?

Back 22

Ancef (IV/IM)
-renal adj.
-1'

Front 23

Brand name of cefadroxil?

Back 23

Duricef (PO)
-renal adj.
-1'

Front 24

Brand name of cephalexin?

Back 24

Keflex (PO)
-renal adj.
-1'

Front 25

Brand name of Cefotetan?

Back 25

Cefotan (IV/IM)

Front 26

Brand name of cefoxitin?

Back 26

Mefoxin
-IV/IM
-2'

Front 27

Brand name of cefuroxime?

Back 27

Zinacef
-IV/IM
-2'

Front 28

Brand name of cefuroxime?

Back 28

Ceftin
-PO
-2'

Front 29

Brand name of cefprozil?

Back 29

Cefzil
-PO
-2'

Front 30

Brand name of cefaclor?

Back 30

Ceclor
-PO
-2'

Front 31

Brand name of Loracarbef?

Back 31

(Lorabid)
-PO
-2'

Front 32

Among 2' cephalosporins, which one can increase INR?

Back 32

Cefotetan (Cefotan)

Front 33

Brand name of cefotaxime?

Back 33

Claforan
-IV/IM
-3'

Front 34

Brand name of ceftazidime?

Back 34

Fortaz
-IV/IM
-3'

Front 35

Brand name of cefizoxime?

Back 35

Cefizox
-IV/IM
-3'

Front 36

Brand name of Ceftriaxone?

Back 36

Rocephin
-IV/IM
-3'

Front 37

Brand name of Cefepime?

Back 37

Maxipime
-IV/IM
-4'

Front 38

Among 3' of cephalosporins, which one covers pseudomonas?

Back 38

Fortaz (ceftazidime)

Front 39

All 1' and 3' cephalosporins need to be renal adjusted, except ONE in 3' generation. It is_____?

Back 39

Ceftriaxone (Rocephin)

Front 40

Which drugs is accosicated with --?
calcium percipitate
bilirubin displacement
gallstones and renal stones formation

Back 40

Rocephin (Ceftriaxone)

Front 41

Two drugs in cephalosporins covers pseudomonas?

Back 41

Cefeapime (Maxipime)
Ceftazidime (Fortaz)

Front 42

Among 4 carbapenems, which ONE does not cover pseudomonas?

Back 42

Ertapenem (Invanz)
(IV/IM)

Front 43

What are the 4 carbapenems? (IE,MD)

Back 43

Imipenem / cilastatin (Primaxin)
Ertapenem (Invanz)
Meropenem (Merrem)
Doripenem (Doribax)

*only MD IV only, IE IV/IM

Front 44

What activities does carbapenems cover? What do they not cover?

Back 44

-G (+)/(-)
-Anaerobes
-Pseudomonas (except Erata)

not covering MRSA, VRE, Atypical

Front 45

How does cilastatin prolong drug activity?

Back 45

inhibits dehydropeptidase

Front 46

Which carbapenmen drug has long t1/2, which allows once daily dosing, and uses for intra-abdominal and pelvic infection?

Back 46

Ertapenem (Invanz)
-IV/IM

Front 47

What spectrum does monobactam cover? What drug is in that class?

Back 47

Aztreonam (Azactam)
-G (--) only
-Including pseudomonas and enterobacteriaceae
-renal adjust

Front 48

Which drug binds to d-alanyl-dalanine dipeptide of peptidoglycan subunits and preventing from being incorporated into the cell wall?

Back 48

Vancomycin

Front 49

Dosing of vanco, trough value, loading dose. Time dependent killing or concentration dependent killing?

Back 49

dosing: 15-20 mg/kg;
loading: 25-30 mg/kg
trough value: 15-20 mg/kg
Time dependent killing

Front 50

MOA of this drug:
Lipid portion of this drug inserts into the bacterial cytoplasmic membrane, forming an ion-conducting channel which allows ions to escape from the bacterial, resulting bacterial death

Back 50

Daptomycin

Front 51

Brand name of Daptomycin?

Back 51

Cubicin (daptomycin)

Front 52

ADR of Cubicin (daptomycin)?

Back 52

Myopathy (monitoring CK)

Front 53

Which disease should daptomycin not to treat?

Back 53

Pneumonia; due to pulmonary surfactants inhibition