Abx Afng Moa

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PCN

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competitive inhibitor for transpeptidase enzyme. ; inhibits bacterial cell wall synthesis

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Penicillinase Resistant

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competitive inhibitor for transpeptidase enzyme. ; inhibits bacterial cell wall synthesis

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Amino PCN

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competitive inhibitor for transpeptidase enzyme. ; inhibits bacterial cell wall synthesis

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Anti Pseudomonial PCN

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competitive inhibitor for transpeptidase enzyme. ; inhibits bacterial cell wall synthesis

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Beta Lactamase Inhibitors

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competitive inhibitor for transpeptidase enzyme. ; inhibits bacterial cell wall synthesis

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Vancomycin

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inhibits: cell wall synthsis and RNA synthesis

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Quinolones

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Inhibits bacterial DNA gyrase and topoisomerase IV to impair supercoiling and replication of DNA inside Cell

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1st G Cephalosporins

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Distrupt synthesis of peptidoglycan layer in bacterial cell wall

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2nd G Cephalosporins

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Distrups synthesis of peptidogylcan layer of bacterial cell wall

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3rd Generation

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Distrupt synthesis of peptidoglycan layer of the bacterial cell wall

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Cefepime

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Distrupts synthesis of peptidogycan layer on tbacterial cell wall

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Carbapenems

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lyse bacterial cell wall

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Amino Glycosides

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binds to 30 s bacterial ribosomal subunits and inhibits protien synthesis

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Bactrim

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Inhibits folate synthesis (bacteriocidal)

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Macrolides

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Binds to 50s ribosomal subunit and inhibits protien synthesis

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Tetracyclines

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binds to 30 s bacterial ribosomal subunits and inhibits protien synthesis

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Daptomycin

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Binds to cell membrane and inhibits intracellular synthesis of RNA DNA and protien

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Tigecycline

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Binds to the 30 s subunit and inhibits protieb synthesis

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Telithromycin

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Binds to 50 S ribosomal subunit and inhibits protien syntheiss

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Clindamycin

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Binds to the 50 s ribosomal subunit and inhibits protein synthesis

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Metronidazole

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Reduction reaction depriving organism required reduction equivalebts for DNA (bacteriocidal)

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Synercid

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Binds 2 different sites on the 50 s ribosomal subunit leading to interruption of protein synthesis and cell death

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Linezolid

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Selectively Binds to the 23 s ribosomal RNA of the 50 s subunit preventing complex formation with 70 s ribosomal subunit

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AZOLES

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alters fungail cell membrane by inhibition of ergosterol syntheisis and results in increased cellular permeability causing leakage of contents and cell death (FUNGISTATIC)

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AZOLE DRUGS

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Fluconazole itraconazole voriconazole Posaconazole

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Amphotericin B

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Binds to sterol in the cell membranes of both fungal and human cells (fungistatic)

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Flucytosine

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Penetrates fungal cells converted to 5fu competing with uracil and interfering with pyrimidine metabolism and distrupting both RNA and protien synthesis

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ECHINOCANDINS

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Inhibits synthesis of beta 1,3 d-glycan a fungal cell wall component not found in mamillian cells (fungicidal against Candida)

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Echinocandins examples

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Caspofuingin Micafungin Anigulafungin

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Acyclovir

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Stops replication of herpes DNA through synthetic purin nucleoside analog. Terminates DNA chain and inactivates DNA polymerase

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Valcyclovir

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Stops replication of herpes DNA through synthetic purin nucleoside analog. Terminates DNA chain and inactivates DNA polymerase

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Famciclovir

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Prodrug of penciclovir

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Penciclovir

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active compound that inhibits DNA polymerase by competing with deoxyguanosine triphosphate

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Ganciclovir

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Inhibits viral dna synthesis by competively inhibiting viral dna polymerase and incorporates into viral DNA resulting in chain terminatin

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Valganciclovr

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Inhibits viral dna synthesis by competively inhibiting viral dna polymerase and incorporates into viral DNA resulting in chain terminatin