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25 Cards in this Set
- Front
- Back
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drugs that can cause neutropenia
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clozapine
thionamides (anti-thyroid) anti-consulsants sulfasalazine anti-malarials sulfonylurea 1st gen |
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organisms associated with neutropenia
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Candida
Staph aureus GN from GI/GU |
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common sites of infection in neutropenia
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oral cavity
mucus membranes skin genitalia perianal |
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bands
normal |
0-3%
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CA-MRSA
prevalent strain |
USA 300
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CA-MRSA
virulence factors (6) |
PVL (Panton-Valentine leukocidin)
SCC-mec (Staph cassette chromosome mec) alpha-hemolysin (forms pores) PSM's (phenol soluble modulins) ACME (arginine catalytic mobile element) agr (accessory gene regulator) |
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PVL a/w what?
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USA 300 CA-MRSA virulence factor
SSTI, necrotizing pneumonias |
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UTI pregnancy
definition |
urine cx + x 2 consecutively
with same organism >= 10^5 organisms |
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UTI pregnancy
usual microbes |
E coli (85%)
Staph saprophyticus GBS |
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UTI pregnancy
Tx |
3-7 days
nitrofurantoin cephalexin (1G) cefuroxime (2G) |
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UTI pregnancy
tx contraindicated |
TMP-SMX
no folate antagonists with pregnancy FLQ can cause fetal arthropathy/cartilage malformation |
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Nitrofurantoin
contraindicated |
nitrofurantion contraindicated
G6PD |
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UTI pregnancy
screening |
UC at 12-16 weeks
or 1st prenatal visit if later (Gr A recommendation) |
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fluroquinolones
severe side effects |
tendon rupture / tendonitis
arthropathy/cartilage malformation in fetus in pregnancy |
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UTI
uncomplicated cystitis in women lab diagnosis |
dipstick
+ leukocyte esterase + nitrite cx >10^5 midstream sample >9 WBCs / HPF |
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UTI
uncomplicated cystitis in women Tx |
nitrofurantoin
100 mg bid x 5 days TMP/SMX DS bid x 3d (local resistance to E coli <= 20%) |
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UTI
uncomplicated cystitis in women longer tx when? |
postmenopausal
DM tx for 7 days |
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ICU fever - infectious causes (7)
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VAP, UTI
catheter site surgical site bacteremia phlebitis sinusitis |
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ICU fever - noninfectious causes (9)
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transfusion reaction
mesenteric ischemia acalculous cholecystitis acute pancreatitis DVT / PE thyroid storm malignancy malignant hypertermia drug fever |
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what is malignant hyperthermia
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genetic defect
SR Ca channel receptor reaction when receive inhaled anesthetics esp halothane |
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drug fever - 8 general classes
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anticonvulsants, antimicrobials
allopurinol, heparin chemotherapy neuroleptic malignant syndrome esrotonin syndrome G6PD deficiency |
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drug fever anticonvulsants (3)
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carbamazepine
phenytoin phenobarbital |
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drug fever antimicrobials (4)
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beta-lactams (PCN, cephalosporins, carbamazepems)
sulfonamides nitrofurantoin minocyclin (acne) |
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neuroleptic malignant syndrome
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dopamine depleting agents
esp haloperidol |
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G6PD deficiency and drug fever (2 drugs)
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sulfonamides
quinines |
