Abx 3: Other Moa's

Front 1

Name drugs that are anti-folate production

Back 1

sulfonamides
trimethoprim
methotrexate
dapsone
pyrimethamine

Front 2

Sulfonamides
MOA:
uses:
tox:

Back 2

MOA: inh of DHP-synthase; low folate
uses: gm+, simple gm-, Nocardia, Chlamydia
tox:
Photosensitivity, Anaphylaxis, Rash, Kernicterus, Kidney stones, Interstitial nephritis, Methemoglobinemia, Steven Johnson, Hemolytic Anemia, Displaces meds from albumin
"PARK KIMS HAnDA"

Front 3

Trimethoprim:
MOA:
uses:
tox:

Back 3

MOA: inh DHF-reductase; low folate
uses: combine with sulfa for
1) UTI phx
2) PJP phx
3) rx nocardia
tox: megaloblastic anemia, leukopenia

Front 4

Fluoroquinolones
ex:
MOA:
uses:
S/E:
CI:

Back 4

ex: -oxacin
MOA: inh type 2 and 4 topoisomerase
uses: staph a, all gm-, atypicals
S/E: damaged cartilage in kids, tendonitis & rupture in adults, myalgia
CI: < 9 y/o, preggo

"quiniLONES hurt attachments to your BONES"

Front 5

whats DNA gyrase?

Back 5

type 2 topoisomerase

Front 6

Metronidazole is selectively absorbed by (2)

Back 6

1) anaerobic bacteria
2) protozoa

Front 7

Metronidazole
MOA:
uses:
S/E:

Back 7

MOA:
1) reduced by ferredoxin to produce toxic products that damage DNA
2) inh topoisomerase

uses: Giardia, Entameoba hystolitica, Trichonomas vagititis, Gardnerella (Bactieral vaginosis), Anaerobe below the diaphragm
Pseudomembranous colitis
"GET GAP on the metro"; aslo PUD by Hpylori
S/E: disulfiram rxn, metallic taste, teratogen, methemoglobinemia, hemolytic anemia

Front 8

Name the DHF reductase inh

What are the synthase inh?

Back 8

1) Methotraxate
2) Trimethoprim
3) Pyrimethamine

synthase inh= dapsone, sulfonamides

Front 9

What do we give with the DHF reductase inh, always?

Back 9

folinic acid (leucovorin rescute)

Front 10

uses for Pyrimethamine

Back 10

1) Pyrimethamine+ sulfa=> toxo
2) Pyrimethamine alone => plasmodium falciprum (malaria)

Front 11

Polymyxins
MOA:
uses:
tox:

Back 11

MOA: bind to cell MEMBRANE, disrupt osmotic properties (act like detergents)
uses: gm - resistant to other rxs
S/E: neurotox, ATN

Front 12

Isoniazide
MOA:
uses:
S/E:

Back 12

MOA: dec synthesis of mycolic acids
uses:
1) part of rIpes for rx of TB
2) used alone for TB phx
S/E:
Liver damage, Lupus, Vit B6 dec, Seizures, Myositis, Oxidize RBC's, Neuropathy, Inh P450
"isoniazide LLVS MONI"

Front 13

Rifampin
MOA:
uses:
S/E:

Back 13

MOA: inh RNA polymerase; block Beta subunit
uses:
1) Ripes in rx for TB
2) meningiococcal phx
3) Hib meningitis phx
4) Staph epididimus (after vanc)
S/E: Revs up P450, Rhabdo, Red orange urine

"Rif: RNA poly, Revs, Rhabdo, Red"

Front 14

Ethambutol
MOA:
uses:
S/E:

Back 14

MOA: blocks arabinose (a sugar mycobacterium likes)
uses: MAI phx, ripEs part of rx for TB
S/E: optic neuropathy (red-green color blindness)

Front 15

drugs that block topoisomerase

Back 15

1) quinolones
2) metronidazole