Abx 2: 30/50S Inh

Front 1

30s inhibitors
50s inhibitors

Back 1

30s: Aminoglycosides, Tetracyclines
50s: Chloramphenicol, Clindamycin, Macrolides, Linozelid

"AT-CCML"

Front 2

What does the initiation complex comprise of?

Back 2

1) 30s
2) methylated tRNA
3) mRNA

Front 3

Once the initiation complex is complete what happens?

Back 3

a free portion of methylated tRNA binds to the A site of 50s.

Front 4

Which does tRNA bind to first, 30s or 50s?

Back 4

30s (in forming the initiation complex)

Front 5

50s: Chloramphenicol, Clindamycin, Macrolides, Linozelid

from these, which binds to 50s and inh both
1) translocation
2) peptidyl transferase activity

Back 5

1) Clindamycin
2) Macrolides

Front 6

50s: Chloramphenicol, Clindamycin, Macrolides, Linozelid

from these, which binds to 50s and inhs only peptidyl transferase activity (does not effect translocation)

Back 6

Chloramphenicol

Front 7

50s: Chloramphenicol, Clindamycin, Macrolides, Linozelid

from these, which binds to 50s and inhs both
1) INITIATION
2) peptidyl transferase activity

Back 7

Linozelid

Front 8

30s: Aminoglycosides, Tetracyclines

from these, which binds to 30s and inhs FORMATION of initiation complex?

Back 8

Aminoglycoside

Front 9

30s: Aminoglycosides, Tetracyclines

from these, which binds to 30s and inhs binding of tRNA?

Back 9

Tetracyclines

Front 10

Aminoglycosides
ex:
MOA:
uses:
S/E:

Back 10

ex: NOT ACE-mycin, Amikacin
MOA:
1) binds to 30s and inhs FORMATION of initiation complex (blocks IF-2)
2) missreading of mRNA
3) requires O2 for uptake (not effective against anaerobes)
uses: all gm neg
S/E: Nephrotoxic, Ototoxic, Teratogenic
"NOT"

Front 11

Tetracycline
ex:
MOA:
uses:
S/E:

Back 11

ex: -cycline
MOA: binds to 30s and inhs binding of tRNA...
1) onto the 30s
2) onto the A site of 50s
uses: vibrio, acne, chlamydia, ureaplasma, mycoplasma, tularemia, H pylori, borrelia, rickettsia
"VACUM THe BR"
S/E: stain teeth, inh bone growth, photosensitivity, fanconi syndrome, pancreatitis, odonyphagia

Front 12

Macrolides:
ex:
MOA:
uses:

Back 12

ex: ACES-mycin
MOA: binds to 50s and inh both
1) translocation
2) peptidyl transferase activity
uses: URI, PNA, STD, Legionella, Mycoplasma, Bartonella Henslea, Neisseria, Chlamydia
"UPS Lost My Brand New Car"
***DOC for atypical PNA
S/E: Skin rash, Eosinophila, GI, Acute cholystatic hepatitis, inh P450
"SEGA- Inh P450"

Front 13

What does ACES for macrolides stand for?

Back 13

Azithromycin
Clarithromycin
Erythromycin
Spiramycin

Front 14

Cloramphenicol:
MOA:
uses:
S/E;

Back 14

MOA: binds to 50s and inhs only peptidyl transferase activity by directly inhibiting substrate binding (does not block translocation)
uses: meningitis (strep, Heamoph, Neisseria); is DOC for meningitis in pts with PCN allergy
S/E: aplastic anemia, grey baby

Front 15

Clindamycin
MOA:
uses:
S/E:

Back 15

MOA: binds to 50s and inh both
1) translocation
2) peptidyl transferase activity
uses: anaerobes above the diaphragn (Bacteriodes fragilis, Clostridium perfringes)
S/E: toxic megacolon, Pseudomembranous colitis, fever diarrhea

Front 16

Which 30/50s inh abx can be used
for pts with renal failure? why?

Back 16

1) Amikacin (Aminoglycoside), bc hepatically excreted

2) Doxicylcline (Tetracycline), bc fecally excreted

Front 17

Which 30/50s inh abx should not be given with 2+ ions (milk, iron, antiacids)? why?

Back 17

All tetracylcines. 2+ cations inh absorption in gut.

Front 18

Which 30/50s inh abx is an ADH antagonist?

Back 18

Demecocycline

Front 19

Which 30/50s inh abx causes seizures?

Back 19

Erythromycin (macrolide)

Front 20

Which 30/50s inh abx can be used synergistically with B-lactams?

Back 20

Aminoglycosides

Front 21

Which 30/50s inh abx require O2 for uptake, so are ineffective against anearobes?

Back 21

Aminoglycosides

Front 22

Which 30/50s inh abx increase concentration of oral anticoagulants?

Back 22

Macrolides

Front 23

Which 30/50s inh abx inc concentration of theophylline?

Back 23

Macrolides