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25 Cards in this Set
- Front
- Back
- 3rd side (hint)
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K-ras
|
1) Soft tissue sarcomas
2) Pancreatic cancer (90%) 3) Biliary cancers |
- Proto-Oncogene
- Chromosome 12p |
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RET
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1) MEN-2 (both)
2) Familial medullary thyroid cancer |
- Proto-Oncogene
- Chromosome 10q |
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c-myc
|
1) Breast cancer
2) Colon cancer 3) Cervical cancer 4) Small cell lung cancer |
- Proto-Oncogene
- Chromosome 8q |
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HER2/neu
|
1) Breast cancer (30%)
2) Ovarian cancer 3) Lung cancer 4) Gastric cancer 5) Oral cancers |
- Proto-Oncogene
- Chromosome 17q |
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RB1
|
1) Retinoblastoma
2) Osteosarcoma |
- Tumor Suppressor Gene
- Chromosome 13q |
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p53
|
1) Sarcoma
2) Breast cancer 3) Li-Fraumeni syndrome |
- Tumor Suppressor Gene
- Chromosome 17p |
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BRCA1
|
1) Familial breast cancer
2) Ovarian cancer |
- Tumor Suppressor Gene
- Chromosome 17q |
|
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BRCA2
|
1) Familial breast cancer
(esp. Male) 2) Pancreatic cancer 3) Prostate cancer |
- Tumor Suppressor Gene
- Chromosome 13q |
|
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STK11
|
Peutz-Jeghers syndrome
|
- Tumor Suppressor Gene
- Chromosome 19p |
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MENIN
|
MEN-1
(not MEN-2) |
- Tumor Suppressor Gene
- Chromosome 11q |
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CDKN2
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1) Familial atypical multiple mole melanoma syndrome
2) Pancreatic cancer |
- Tumor Suppressor Gene
- Chromosome 9p |
|
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PTEN
|
Cowden's syndrome
(hamartomas) |
- Tumor Suppressor Gene
- Chromosome 10q |
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WT1
|
Wilm's tumor
|
- Tumor Suppressor Gene
- Chromosome 11p |
|
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VHL
|
von Hippel-Lindau
- Renal cell carcinoma - Pheochromocytoma - Retinal angioma |
- Tumor Suppressor Gene
- Chromosome 3p |
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APC
|
Familial adenomatous polyposis
|
- Tumor Suppressor Gene
- Chromosome 5q |
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CA 19-9
|
Pancreatic cancer
|
- Tumor Marker
|
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CEA
|
Colorectal cancer
|
- Tumor Marker
|
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CA 125
|
Ovarian cancer
|
- Tumor Marker
|
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AFP
|
Hepatocellular cancer
(only + in 60% tumors <2cm) |
- Tumor Marker
|
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hCG
|
Nonseminomatous testicular cancer
|
- Tumor Marker
|
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Tyrosinase
|
Melanoma
|
- Tumor Marker
|
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MEN Syndromes
|
- Derived from APUD cells
- Autosomal dominant - 100% penetrance (variable expressivity) |
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MEN-1
|
1) Parathyroid hyperplasia
2) Pancreatic islet cell tumors 3) Pituitary adenoma |
OTHER INFO
1) 4-gland resection, autotranplant 2) Gastrinoma #1 3) Prolactinoma #1 ***CORRECT HYPERPARA FIRST |
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MEN-2a
|
1) Parathyroid hyperplasia
2) Pheochromocytoma 3) Medullary thyroid cancer |
OTHER INFO
1) 4-gland resection, autotranplant 2) Often bilateral, often benign 3) #1 symptom & cause of death ***CORRECT PHEO FIRST |
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MEN-2b
|
1) Pheochromocytoma
2) Medullary thyroid cancer 3) Mucosal neuromas 4) Marfan's habitus 5) Musculoskeletal defects |
OTHER INFO
1) Often bilateral, often benign 2) #1 symptom & cause of death ***CORRECT PHEO FIRST |
