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20 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Three initial responses to vascular injury
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Vasoconstriction, platelet adhesion, thrombin generation
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Intrinsic pathway = __ + __ + __ + __
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exposed collagen, prekallikrein, HMW kininogen, factor XII
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Intrinsic pathway cascade
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XII --> XI --> IX + VIII --> X + V ---> convert prothrombin (factor II) to thrombin --> thrombin converts fibrinogen to fibrin
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Extrinsic pathway sequence
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TF (injured cells) + factor VII --> activate X, then add V --> convert prothrombin to thrombin --> thrombin converts fibrinogen to fibrin
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Prothrombin complex consists of __
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X, V, Ca, platelet factor 3, and prothrombin. Where does it form? What does it catalyze?
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On platelets. Formation of thrombin.
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What is the convergence point for both intrinsic and extrinsic pathways?
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Factor X
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___ combines with platelets to form ____, leading to ___
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Fibrin, platelet plug, hemostasis
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Which factor helps crosslink fibrin?
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XIII
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What are thrombin's roles?
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Key to coagulation, converts fibrinogen to fibrin and fibrin split products, activates factors V and VIII, activates platelets
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How does antithrombin III work?
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Binds and inhibits thrombin, inhibits factors IX, X, XI
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Protein C MOA
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degrades fibrinogen
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Protein S MOA
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Protein C cofactor
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tPA is released from ___ and works by ___
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endothelium, converts plasminogen to plasmin
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Plasmin functions by ___
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degrading factors V and VIII, fibrinogen and fibrin
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Factor with shortest half life
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Factor VII
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Labile factors. Activity lost in stored blood.
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Factors V and VIII. Activity isn't lost in ___.
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FFP
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Only factor not synthesized in liver. Synthesized in ___.
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VIII, endothelium
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Vitamin K takes ___ hours to take effect
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6
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FFP's effect lasts __ hours
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6
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Normal half life of RBCs, platelets, PMNs:
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120 days, 7 days, 1-2 days
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