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36 Cards in this Set

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Exposed collagen + prekallilrein +HMW kinonogen + factor XII
Intrinsic Pathway
Factor XII
Intrinisic pathway
Exposed collagen + prekallilrein +HMW kinonogen + factor XII
activate XI
XI
activates IX + VIII
IX + VIII
activate X + V
X + V
Converts Prothrombin (Factor II) to thrombin
Prothrombin
Factor II
Thrombin
Converts fibrinogen to fibrin
Tissue Factor (injured cells) + factor VII
Extrinsic pathway
Tissue Factor (injured cells) + factor VII
Activates X + V
X + V
Converts Prothrombin (Factor II) to thrombin
Thrombin
-Converts fibrinogen to fibrin
-Catalyzed by the prothrombin complex
Prothrombin Complex
-X, V, Ca, platelet factor 3, and prothrombin
-Forms on platelets
-Catalyzes the formation of thrombin
Factor X
Convergence point and common to both pathways
Tissue factor pathway inhibitor
Inhibits factor X
Fibrin
combines with platelets to form platelet plug--> hemostasis
XIII
(Thirteen)
helps crosslink fibrin
Thrombin
-Key to coagulation
-Fibrinogen->Fibrin and fibrin split products
-activates V and VIII
-activates platelets
Shortest half life
Factor VII
-Activity NOT lost in FFP
-Activity lost instored blood
Factors V and VIII
Vitamin K-dependent factors
II, VII, IX, X, Proteins C and S
Vit K
takes 6 hours to take effect
FFP
Immediate and lasts for 6 hours
Factor II
Prothrombin
Half life of RBC's
120 days
Half life of platelets
7 days
Half life of PMN's
1-2 days
Antithrombin III
-Key to anticoagulation
-Binds to and inhibits thrombin
-Inhibits factors IX, X, XI
Heparin
Binds to AT III
ACTIVATES AT III
Protein C
-Vit K dependent
-Degrades V and VIII
-Degrades fibrinogen
Protein S
-Vit K dependent
-Protein C cofactor
TPA
released from endothelium and converts plasminogen to plasmin
Plasmin
-degrades factors V and VIII, fibrinogen, and fibrin ->lose platelet plug
Alpha-2 antiplasmin
natural inhibitor of plasmin, releasedfrom endothelium
PGI 2
from ?
? platelet aggregation
? vasodilation
? to TXA 2
-from endothelium
-decreases platelet aggregation
-promotes vasodilation
-antagonistic to TXA 2
TXA2
from ?
? platelet aggregation
? vasoconstriction
-from platlets
-increases platelet aggregation
-promotes vasoconstriction