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36 Cards in this Set
- Front
- Back
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Exposed collagen + prekallilrein +HMW kinonogen + factor XII
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Intrinsic Pathway
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Factor XII
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Intrinisic pathway
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Exposed collagen + prekallilrein +HMW kinonogen + factor XII
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activate XI
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XI
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activates IX + VIII
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IX + VIII
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activate X + V
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X + V
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Converts Prothrombin (Factor II) to thrombin
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Prothrombin
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Factor II
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Thrombin
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Converts fibrinogen to fibrin
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Tissue Factor (injured cells) + factor VII
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Extrinsic pathway
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Tissue Factor (injured cells) + factor VII
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Activates X + V
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X + V
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Converts Prothrombin (Factor II) to thrombin
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Thrombin
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-Converts fibrinogen to fibrin
-Catalyzed by the prothrombin complex |
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Prothrombin Complex
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-X, V, Ca, platelet factor 3, and prothrombin
-Forms on platelets -Catalyzes the formation of thrombin |
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Factor X
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Convergence point and common to both pathways
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Tissue factor pathway inhibitor
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Inhibits factor X
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Fibrin
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combines with platelets to form platelet plug--> hemostasis
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XIII
(Thirteen) |
helps crosslink fibrin
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Thrombin
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-Key to coagulation
-Fibrinogen->Fibrin and fibrin split products -activates V and VIII -activates platelets |
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Shortest half life
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Factor VII
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-Activity NOT lost in FFP
-Activity lost instored blood |
Factors V and VIII
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Vitamin K-dependent factors
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II, VII, IX, X, Proteins C and S
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Vit K
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takes 6 hours to take effect
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FFP
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Immediate and lasts for 6 hours
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Factor II
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Prothrombin
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Half life of RBC's
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120 days
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Half life of platelets
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7 days
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Half life of PMN's
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1-2 days
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Antithrombin III
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-Key to anticoagulation
-Binds to and inhibits thrombin -Inhibits factors IX, X, XI |
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Heparin
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Binds to AT III
ACTIVATES AT III |
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Protein C
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-Vit K dependent
-Degrades V and VIII -Degrades fibrinogen |
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Protein S
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-Vit K dependent
-Protein C cofactor |
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TPA
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released from endothelium and converts plasminogen to plasmin
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Plasmin
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-degrades factors V and VIII, fibrinogen, and fibrin ->lose platelet plug
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Alpha-2 antiplasmin
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natural inhibitor of plasmin, releasedfrom endothelium
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PGI 2
from ? ? platelet aggregation ? vasodilation ? to TXA 2 |
-from endothelium
-decreases platelet aggregation -promotes vasodilation -antagonistic to TXA 2 |
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TXA2
from ? ? platelet aggregation ? vasoconstriction |
-from platlets
-increases platelet aggregation -promotes vasoconstriction |
