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5 Cards in this Set
- Front
- Back
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Blood groups |
Based on the presence or absence of previous antigen blood is categorised into different blood groups There are at least 24 blood groups |
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ABO antigens |
Are complex oligosaccharides present in form glycoproteins and glycolipids In the formation of A and B antigen, H molecule (coded by H gene) acts as a precursor |
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A antigen |
H contains and additional N-acetylgalactosamine (GalNAc). The addition of the terminal GalNAc to the H molecule is catalysed by GalNAc transferase is a product of A gene |
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B antigen |
In case of B antigen an additional galactose (gal) is linked to H molecule The product of the B gene is the Gal transferase adding the gal residue to the H molecule |
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What happens if a person with type A blood group receives transfusion of type B blood |
The anti-B antibodies in the recipients plasma can bind to the B antigens on the donors RBC causing agglutination and haemolyses of the RBCs The anti-a antibodies in the donor’s plasma can bind to the A antigen on the recipients RBCs causing agglutination and haemolyses of the RBCs |
