Ablab3 Quiz 1

Front 1

Hydrochlorothiazide Brand

Back 1

Microzide

Front 2

Hydrochlorothiazide Therapeutic Class

Back 2

Diuretic
Thiazide

Front 3

Hydrochlorothiazide Common Indications

Back 3

Hypertension

Front 4

Hydrochlorothiazide Common Dosing

Back 4

Oral 12.5-50 mg/day

Front 5

Hydrochlorothiazide Absolute CIs

Back 5

Hypersensitivity to...
-HCTZ
-Thiazides
-Sulfonamide-derived drugs

Renal Decompensation
Pregnancy

Front 6

Hydrochlorothiazide Common Side Effects

Back 6

HoTN
Phototoxicity
Vertigo

Front 7

Hydrochlorothiazide Serious Side Effects

Back 7

HYPER calcemia, glycemia, phosphatemia

HYPO kalemia, magnesemia, natremia

Cardiac dysrhythmia
Pancreatitis
Cholestatic Jaundice Syndrome
Glaucoma
Renal Failure
Renal impairment

Front 8

Hydrochlorothiazide Pregnancy

Back 8

B

Front 9

Hydrochlorothiazide Admin

Back 9

May admin c food or milk; take early in day to avoid nocturia (no later than 6 pm unless instructed otherwise)

Front 10

Hydrochlorothiazide MOA

Back 10

Hydrochlorothiazide is an antihypertensive and diuretic agent that affects the electrolyte reabsorption at the distal renal tubule resulting in increased excretion of sodium and chloride in equal amounts.

Front 11

Acetazolamide Brand

Back 11

Diamox

Front 12

Acetazolamide Therapeutic Class

Back 12

Anticonvulsant
Carbonic Anhydrase Inhibitor; Diuretic
Opthalmic Agent, Antiglaucoma

Front 13

Acetazolamide Common Indications

Back 13

Mountain or altitude sickness
Urine alkalinization

Front 14

Acetazolamide Common Dosing

Back 14

Mountain sickness: oral 500-1000 mg daily Q 8-12 hr (IR) or Q 12-24 hr (ER)

Urine alkalinization: oral 5 mg/kg/dose bid or tid

Front 15

Acetazolamide Absolute CIs

Back 15

Hypersensitivity to acetazolamide or sulfonamides
Hepatic disease or insufficiency
DEC Na or K levels
Adrenocortical insufficiency
Cirrhosis
Hyperchloremic acidosis
Severe renal disease
Severe pulmonary obstruction

Front 16

Acetazolamide Common Side Effs

Back 16

?

Front 17

Acetazolamide Serious SEs

Back 17

SJS
TEN due to drug
acidosis
metabolic acidosis
agranulocytosis
aplastic anemia
thrombocytopenia
hepatic necrosis
anaphylaxis
angle closure glaucoma

Front 18

Acetazolamide Pregnancy

Back 18

C

Front 19

Acetazolamide Administration

Back 19

may admin with food
cause alteration in taste
use cherry or chocolate syrup to disguise taste of druge but not fruit juices

Front 20

Acetazolamide MOA

Back 20

inhibits carbonic anhydrase from catalyzing the reversible hydration of carbon dioxide and dehydration of carbonic acid. In the eye, carbonic anhydrase inhibition reduces aqueous humor production resulting to a decrease in intraocular pressure. It also delays abnormal, paroxysmal excessive discharge from central nervous system neurons and affects promotion of diuresis and urinary alkalinization

Front 21

Furosemide Brand

Back 21

Lasix

Front 22

Furosemide Therapeutic class

Back 22

diuretic, loop

Front 23

Furosemide CI

Back 23

edema in heart failure

Front 24

Furosemide Comm Dosing

Back 24

Oral: 20-80 mg/dose
IM/IV: initial 20-40 mg/dose
Cont IV:
-bolus: 20-40 mg/dose over 1-2 min
-cont 10-40 mg/hr

Front 25

Furosemide Absolute CI

Back 25

Hypersensitivity
anuria
fluid and electrolyte depletion

Front 26

Furosemide Comm SE

Back 26

HYPERURICEMIA (40%)
Hypomagnesemia
loss of app
spasm of bladder

Front 27

Furosemide Serious SE

Back 27

Orthostatic hypotension
Erytheme multiforme
SJS
Pancreatitis
Agranulocytosis and aplastic anemia are rare
thrombocytopenia

Front 28

Furosemide Pregnancy

Back 28

C

Front 29

Furosemide Admin

Back 29

IV inj should be given slowly
admin on empty stomack
c food or milk if GI distress (can reduce diuretic efficacy

Front 30

Furosemide MOA

Back 30

Furosemide is an anthranilic acid derivative and a potent diuretic that works by blocking the absorption of sodium and chloride in the kidney tubules (proximal and distal tubules, also in the loop of Henle), causing a profound increase in urine output

Front 31

Spironolactone Brand

Back 31

Aldactone

Front 32

Spironolactone Therapeutic Class

Back 32

Diuretic, Potassium Sparing
Selective aldosterone blocker

Front 33

Spironolactone Comm Indication

Back 33

edema or heart failure

Front 34

Spironolactone Comm Dosing

Back 34

Oral 25-200 mg/day in 1-2 divided doses
Severe HF: 12.5-25 mg/day... max 50 mg/day

Front 35

Spironolactone Absolute CI

Back 35

Anuria
Acute renal insufficiency
Sig impairment of renal excretory fxn
Hyperkalemia
bbw tumorigenic

Front 36

Spironolactone Common SEs

Back 36

Rash, urticaria, gynecomastia, NVD, stomach cramps, HA, lethargy, somnolence, confusion, menstruation disorder, impotence

Front 37

Spironolactone Serious SEs

Back 37

Skin uler
Hyperkalemia
Metabolic acidosis
gastric hemorrhage
gastritis
agranulocytosis
sle
breast cancer

Front 38

Spironolactone Pregnancy

Back 38

C

Front 39

Spironolactone Admin

Back 39

taken with food
-dec gi irritation
excessive K intake should be avoided

Front 40

Spironolactone MOA

Back 40

It inhibits the effect of aldosterone by competing for the aldosterone-dependent sodium-potassium exchange site in the distal tubule cells. This increases the secretion of water and sodium, while decreasing the excretion of potassium

Front 41

Sodium Polystyrene Sulfonate Brand

Back 41

Kayexalate

Front 42

Sodium Polystyrene Sulfonate Therapeutic Class

Back 42

Antidote

Front 43

Sodium Polystyrene Sulfonate Comm Indic

Back 43

hyperkalemia

Front 44

Sodium Polystyrene Sulfonate Comm Dosing

Back 44

oral 15g 1-4 times/day
rectal 30-50 g every 6 hrs

Front 45

Sodium Polystyrene Sulfonate Abs CI

Back 45

Hypersensitivity
-hypokalemia
-obstructive bowel disease
-neonates with reduced gut motility
-oral admin in neonates!

Front 46

Sodium Polystyrene Sulfonate Common SEs

Back 46

Constipation
nv

Front 47

Sodium Polystyrene Sulfonate Serious SEs

Back 47

Hypocalcemia
Hypokalemia
Fecal Impaction
GI Hemorrhage
GI necrosis
GI obstruction/perforation
ischemic colitis
acute bronchitis
bronchopneumonia

Front 48

Sodium Polystyrene Sulfonate Pregnancy

Back 48

C

Front 49

Sodium Polystyrene Sulfonate Admin

Back 49

Shake suspension well
do not mix with orange juice
oral admin more eff

Front 50

Sodium Polystyrene Sulfonate MOA

Back 50

Local: Antihyperkalemic—In the intestine (mostly the large intestine), sodium ions are released and are replaced by potassium and other cations before the resin is passed from the body.

Front 51

Calcitriol Brand

Back 51

Rocaltrol

Front 52

Calcitriol Therapeutic Class

Back 52

Vit D analog

Front 53

Calcitriol Comm Indics

Back 53

Vit D therapy in CKD

Front 54

Calcitriol Common Dosing

Back 54

oral .25 mcg/day

Front 55

Calcitriol Absolute CIs

Back 55

hypersensitivity
hypercalcemia
vit d toxicity

Front 56

Calcitriol Common SEs

Back 56

hypercalcemia

Front 57

Calcitriol Serious SEs

Back 57

acute blistering dermatitis
poisoning by vit d
hypercalcemia syndrome

Front 58

Calcitriol Pregnancy

Back 58

C

Front 59

Calcitriol Admin

Back 59

admin with regard to food

Front 60

Calcitriol MOA

Back 60

an active form of vitamin D(3) or cholecalciferol, stimulates calcium transport in the intestines, its resorption in bones and tubular reabsorption in the kidney. It also suppresses the parathyroid hormone (PTH) secretion and synthesis

Front 61

Ergocalciferol Brand

Back 61

Drisdol

Front 62

Ergocalciferol Therapeutic Class

Back 62

Vit D Analog

Front 63

Ergocalciferol Comm Indics

Back 63

Vit D deficiency/insuff in CKD

Front 64

Ergocalciferol Common Dosing

Back 64

look at dosing

Front 65

Ergocalciferol Absolute CIs

Back 65

Hypersensitivity
hypercalcemia
malabsorption syndrome
hypervitaminosis d or abnormal sensitivity to toxic effs of vit d

Front 66

Ergocalciferol Common SEs

Back 66

n/a

Front 67

Ergocalciferol Serious SEs

Back 67

hypercalcemia
hypervitaminosis d
renal impairment
calcification of soft tissues
bone demineralization
growth retardation
nc
mild acidosis
wt loss

Front 68

Ergocalciferol pregnancy

Back 68

c

Front 69

Ergocalciferol admin

Back 69

n/a

Front 70

Ergocalciferol moa

Back 70

Ergocalciferol, or vitamin D(2), promotes active absorption of calcium and phosphorus, thus increasing serum calcium and phosphate levels sufficiently to allow bone mineralization. It also mobilizes calcium and phosphate from bone and increases the reabsorption of calcium and phosphate by the renal tubules

Front 71

Desmopressin Brand

Back 71

DDAVP

Front 72

Desmopressin Therapeutic Class

Back 72

Antihemophillic agent
hemostatic agent
vasopressin analog, synthetic

Front 73

Desmopressin Comm Indics

Back 73

Diabetes insipidus

Front 74

Desmopressin Comm dosing

Back 74

look at dosing

Front 75

Desmopressin Abs CIs

Back 75

hypersensitivity hyponatremia
history of mod to sev renal impairment

Front 76

Desmopressin Comm SEs

Back 76

flushing
nausea
fatigue
ha

Front 77

Desmopressin Serious SEs

Back 77

abnormal bp (infreq)
inc hr
hyponatremia
hyposmolality
water intox syndrome
thromboembolic disorder
acute allergic rxn
anaphylaxis and seizure rare

Front 78

Desmopressin Pregnancy

Back 78

B

Front 79

Desmopressin Admin

Back 79

withdraw dose from ampule... further dilution not reqd
admin as direct inj

Front 80

Desmopressin moa

Back 80

Desmopressin acetate is a synthetic analogue of the naturally occurring hormone 8-arginine vasopressin (ADH) and an antidiuretic hormone that affects conservation of water in the kidneys. It has lesser vasopressor activity and action on visceral smooth muscles relative to the enhanced antidiuretic activity.

Front 81

Pot Chl Brand

Back 81

Klor-Con

Front 82

Pot Chl Therapeutic Class

Back 82

Electrolyte supplement
oral/parenteral

Front 83

Pot Chl Comm Indics

Back 83

prevention hypokalemia
tx hypokalemia

Front 84

Pot Chl Comm Dosing

Back 84

Prevention: oral/iv 20-40 meQ/DAY
TX: 40-100 meq/day divided in 2-5 doses

Front 85

Pot Chl Abs CI

Back 85

hypersensitivity hyperkalemia
oral ci in pt with gi tract passage delays

Front 86

Pot Chl Comm SEs

Back 86

NVD
flatulence

Front 87

Pot Chl Serious SEs

Back 87

Cardiac arrest
abnormal ecg
hyperkalemia
abdominal pain
gi ulcer

Front 88

Pot Chl pregnancy

Back 88

c

Front 89

Pot Chl admin

Back 89

with meals and full glass of water to minimize gi irritation

Front 90

Pot Chl moa

Back 90

Potassium chloride, an electrolyte replenisher, participates in several physiological processes in the body including the transmission of nerve impulses, the maintenance of normal renal function and intracellular tonicity, and the contraction of skeletal, cardiac and smooth muscle

Front 91

Bosentan Brand

Back 91

Tracleer

Front 92

Bosentan Therapeutic Class

Back 92

Endothelin antagonist
Vasodilator

Front 93

Bosentan Comm Indics

Back 93

Pulmonary artery HTN

Front 94

Bosentan Comm Dosing

Back 94

oral <40 kg
initial and maint 62.5 mg
oral >40kg
initial 62.5 mg
maint 125 mg bid

Front 95

Bosentan Absolute CI

Back 95

HYPERSENSITIVITY CONCURRENT USE OF CYCLOSPORINE OR GLYBURIDE
pregnancy

Front 96

Bosentan Comm SEs

Back 96

Edema of lower extremity
hypotension
palpitations
flushing
dec hgb
ha

Front 97

Bosentan Serious SEs

Back 97

dec hgb
liver cirrhosis
inc liver aminotransferase level
liver failure
angioedema

Front 98

Bosentan Pregnancy

Back 98

C

Front 99

Bosentan Admin

Back 99

may admin with or without food
once am
once pm

Front 100

Bosentan moa

Back 100

Bosentan is a dual endothelin receptor antagonist.
Bosentan decreases both pulmonary and systemic vascular resistance resulting in increased cardiac output without increasing heart rate.