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10 Cards in this Set
- Front
- Back
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What is 2,3-DPG?
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2,3-diphosphoglycerate. Binds to deoxygenated Hb, causing it to unload remaining O2.
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What shifts the O2 curve to the right?
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Acidosis, Hyperthermia, increased pCO2, increased DPG
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What is the p50 of the O2/Hb dissociation curve?
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27 mmHg
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How is the A-a gradient calculated?
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PAO2-PaO2
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What affects A-a gradient?
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R-L shunt, V/Q scatter, mixed-venous O2 tension
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How is A-a gradient related to R-L shunt?
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Directly proportional (larger R-L shunt -> greater A-a gradient)
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How is A-a gradient related to mixed venous O2 tension?
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Inversely: Low MVO2 -> decreased returning O2 in returning blood -> less O2 in arteries, thus increasing A-a gradient
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What is a normal A-a gradient?
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<15 mmHg
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What is the effect of increasing FiO2 on A-a gradient?
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Directly proportional
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What is the formula for CaO2?
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1.34 x Hb x SaO2 + 0.003 x PO2
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