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35 Cards in this Set
- Front
- Back
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What cytokine provides autocrine signals to activated T cells leading to expansion of antigen-specific clone?
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IL-2
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Name the process whereby an intracellular viral or tumor cell can be presented, by dendritic cells, to an MHC Class II CD4 naive T cell?
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Cross priming, or cross presentation
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Is CD-40 constitutive or induced?
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CD-40 is constitutively expressed
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Is CD-40L (CD-154) constitutive or induced?
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CD-40L is induced
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Activation of ZAP70 can lead to activation of the PLCgamma 1, DAG, PKC pathway that can lead to activation of this transcription factor
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NF-kappaB
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Activation of Zap 70 can lead to activation of PLCgamma 1, DAG, PCK pathway to increase cytosolic CA2+ and ultimately lead to this transcription factor
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NFAT
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Activation of ZAP70 can lead to activation of RAS, MAP kinace cascade that can lead to activation of this transcription factor
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AP-1
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After phosphorylation, ITAMs on the zeta chain of the TCR become an important docking site for this important tyrosine kinase
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ZAP-70
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Antigen recognition and CD-28 stimulation on T cells leads to T cell surface expression of thsi important B cell costimulatory molecule
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CD-40 ligand (CD-154)
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Cyclosporine and Tacrolimus would lead to reduced activation of this transcription factor
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NFAT
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This receptor has the highest binding affinity for CD 80
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CTLA-4
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This is the inhibitory ligand for B7-1
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CTLA-4
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Stimulatory ligand of CD86
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CD-28
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The tyrosine kinase associated with CD4 and CD8 that phosphorylates the ITAMS on CD3 and the zeta chain
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Lyk
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T/F - I kappa B is a stimulatory molecule that binds NF-kappa B and assists its transport across the nuclear membrane
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False
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T/F - A mature B cell can have IgM and IgD coexpressed on the surface?
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True
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T/F - Fos and Jun are cofactors that, when combined, make AP-1
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True
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T/F - CD45RA T cells express CTLA4 constitutively?
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False
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This protein is a key step in T cell activation involving ZAP-70 phosphorylation
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LAT (linker for the activation of T cells)
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T/F - the natural migration of T cells in the thymus goes from double negative to single positive to double positive
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False
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What molecules express B-7 molecules?
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Dendritic cells, macrophages, and B lymphocytes
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Name a major cytokine that increases the expression of B7 costimulators
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IFN-gamma
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Name the CD marker for ICOS
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CD-278
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Name the CD marker for ICOS-ligand
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CD-275
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Is ICOS constitutively or inducibly expressed?
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Induced
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ICOS is important for timulating the production of what major cytokine
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IL-10
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CD3- associated tyrosine kinase
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Fyn
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What mediators of transcription factor signaling are G protein coupled?
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RAS/ RAC
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NAme the integrains in the p-smac that serve for stabilization of the T cell
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ICAM - 1 and LFA-1 (CD11a/CD18)
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Name the components of the RAS cascade, including the intermediate steps and its final contribution to AP-1
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RAS/GTP - ERK - ELK - Fos
(Fos + Jun = AP1) |
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Name the components of the RAC cascade, including the intermediate steps and its final contribution to AP-1
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RAC/GTP - JNK - JUN
(Fos + Jun = AP1) |
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NFAT is the transcription factor for what major cytokine genes
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IL2, IL4, TNF
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What is the CD marker for PD-1
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CD-279
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What is PD-1, and is it inducible or constitutive
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PD-1 is an inducible inhibitory receptor on Tcells, Bcells and monocytes of the CD28family. It binds to PD-L1 and PDl2 (homologous to B71 and B72)
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Name the major E3 ligase that targets the TCR for ubiquination and degredation (resulting in stopp of signaling)
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Cbl-b binds to ZAP70 and ubiquinates it as well as the TCR complex, leading to its degredation
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