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16 Cards in this Set
- Front
- Back
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T-cells are specific for ___________
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amino acid sequences of peptides
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self MHC restriction
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T-cells from any one individual recognize foreign peptide antigens only when these peptides are bound to and displayed by the MHC molecule of that individual
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CD1
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Class-I like non-polymorphic molecule, expressed on a variety of APC's and epithelia
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5 types of cells that recognize CD1
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CD4+; CD8+; CD4-CD8- alpha/beta T-cells.
Gamma/delta T-cells. NK-T cells |
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Adjuvants
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Products of microbes, or molecules that mimic microbes, to stimulate a T-cell response
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The most effective APC's for activating naive CD4+ and CD8+ T-cells.
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Dendritic cells.
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The most effective APC's for presenting antigens to differentiated (effector) CD4+ T-cells during cell-mediated immune responses.
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Macrophages
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The most effective APC's for presenting antigens to helper T-cells during a humoral immune response.
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B-cells
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IL-4 increases class II MHC expression in what APC types?
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B-cells
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Interferon-gamma increases class II MHC expression in what APC types?
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dendritic cells, macrophages, vascular endothelial cells, various epithelial and mesenchymal cells
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Following activation, what chemokine receptor do dendritic cells express?
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CCR7 (same chemokine receptor as naive T-cells); leads dendritic cell into T-cell zone of lymph node
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Half-life of class II MHC in immature dendritic cell
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10 hours
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Half-life of class II MHC in mature dendritic cell
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>100 hours
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What costimulators do dendritic cells express after activation to activate T-cells?
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B7, ICAM-1, IL-2
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Cross-presentation
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One cell type can present antigens from another cell and prime (or activate) T-cells specific for this antigen. (i.e. a dendritic cell can ingest a viral-infectec or tumor cell and present antigens from these cells on class I MHC molecules).
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The central reaction of cell-mediated immunity
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Macrophages present the antigens of phagocytosed microbes to effector T-cells, which activate the macrophages to kill the microbes.
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