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22 Cards in this Set
- Front
- Back
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He used genetic techniques to study the rejection of transplanted tumors on laboratory mice, leading to discovery of histocompatibility genes.
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George Snell, 1940
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Human MHC genes are equivalent to _____ genes of the mouse
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H-2 molecules
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Chromosome containing HLA genes
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Chromosome 6
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What HLA genes were discovered using family studies to map the HLA locus
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HLA A, B, and C
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What HLA genes were found using the mixed leukocyte reaction (MLR)
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HLA DP, DQ, DR
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MHC Class I corresponds with what HLA genes?
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HLA A, B, and C
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MHC Class II corresponds with what HLA genes?
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HLA DR, DP, DQ
(think Class 2 and 2 letters the HLA) |
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What are the polypeptide chains of the Class I MHC
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a and B2
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What are the polypeptide chains of the Class II MHC
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a and B
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What are the locations of the Class I MHC polymorphic residues
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a1 and a2
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What are the locations of the polymorphic residues in Class II MHC
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a1 and B1
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What is the binding site for T cell co-receptor in Class I MHC
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a3
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What is the binding site for T cell co-receptor in Class II MHC
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B2
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What chromosome contains the B2 microglobulin?
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Chromosome 15
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In Class II MHC, what chain is the most polymorphic?
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B > a
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How many MHC class II genes does a person inherit?
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Either 6 or 8
DPA1 and DPB1 DQA1 and DQB1 DRA1, DRB1 and possibly DRB3, 4 or 5 |
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How many peptides can a class I or class II MHC bind at a time?
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Only 1 peptide at a time
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What protein used in loading Class I is found in the MHC class II gene locus?
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TAP (transporter associated protein)
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What cells express Class I MHC
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All nucleated cells
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What cells express Class II MHC
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Dendritic cells, B lymphocytes, macrophages and a few other cells that abbas didn't list
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Class II MHC associates with what T cell type?
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CD4+ T helper cells
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Class I MHC associated with what T cell type?
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CD8+ cytolytic T cells
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