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22 Cards in this Set

  • Front
  • Back
categories of angina drugs
nitrates, ccb both dihydropyridine and non dihydropyridine, and beta blockers
MOA of nitrates
NO donor, stimulates guanyl cyclase, smooth muscle relaxation via dephosphorylation of MLC k
clinical use of nitrates
amyl nitrate and sublingual nitro are immediate relief, others are for long ter mx of stable angina, vasospastic and unstable angina
tox of nitrates
orthostatic hypotension, reflex tachy, drug interaction with ED (cGMP specific phosphodiesterase inhibitors
ccb dihydropyridine name
all pine
ccb dihydropyridine MOA
blockade open calcium channels on smooth muscle, decrease calcium mediated contraction, decreaser myocardial O2 requirement
which ccb dhp for stable and vasospasctic angina
nife, amio, nicard
which for raynauds phenom
nife, felo,
which for subarachnoid hemmorhage
ccb non- dihydropyridines
bepridil, diltiazam, verapamil
MOA of bepridil
same as nifedipine but more cardio effects, also blocks Na nd K
MOA of diltiazem and verapamil
same as nifedipine but more cardiac effects, decreased contraction, conduction, velocity, HR
use of bepridil
stable and vasospastic angina,SVT arrythmia
use of diltiazem
stable and vasospastic angina, SVT, raynauds
use of verapamil
stable and vasospastic angina,SVT arrythmia
tox of bepridil
arrythmias, torsades
tox of diltiazem
hypotension, flushing, bradycardia,
tox of verapamil
hypertension, myocardial depression, dependent edema
beta blockers for angina
propran, meta, nadol, aten
MOA of angina beta blockers
decrease in HR, BP, and contractility, decrease in myocardial O2 requirement at rest and during exercise
use of angina bb
stable and unstable angina, not vasospastic, decreased death due to MI, good for pt with htn and as a combination to decrease reflex tachy
contraindications of bb
bradycardia, sick sinus syndrome, LV failure