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22 Cards in this Set
- Front
- Back
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categories of angina drugs
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nitrates, ccb both dihydropyridine and non dihydropyridine, and beta blockers
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MOA of nitrates
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NO donor, stimulates guanyl cyclase, smooth muscle relaxation via dephosphorylation of MLC k
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clinical use of nitrates
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amyl nitrate and sublingual nitro are immediate relief, others are for long ter mx of stable angina, vasospastic and unstable angina
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tox of nitrates
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orthostatic hypotension, reflex tachy, drug interaction with ED (cGMP specific phosphodiesterase inhibitors
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ccb dihydropyridine name
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all pine
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ccb dihydropyridine MOA
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blockade open calcium channels on smooth muscle, decrease calcium mediated contraction, decreaser myocardial O2 requirement
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which ccb dhp for stable and vasospasctic angina
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nife, amio, nicard
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which for raynauds phenom
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nife, felo,
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which for subarachnoid hemmorhage
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nimodipine
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ccb non- dihydropyridines
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bepridil, diltiazam, verapamil
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MOA of bepridil
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same as nifedipine but more cardio effects, also blocks Na nd K
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MOA of diltiazem and verapamil
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same as nifedipine but more cardiac effects, decreased contraction, conduction, velocity, HR
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use of bepridil
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stable and vasospastic angina,SVT arrythmia
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use of diltiazem
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stable and vasospastic angina, SVT, raynauds
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use of verapamil
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stable and vasospastic angina,SVT arrythmia
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tox of bepridil
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arrythmias, torsades
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tox of diltiazem
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hypotension, flushing, bradycardia,
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tox of verapamil
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hypertension, myocardial depression, dependent edema
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beta blockers for angina
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propran, meta, nadol, aten
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MOA of angina beta blockers
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decrease in HR, BP, and contractility, decrease in myocardial O2 requirement at rest and during exercise
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use of angina bb
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stable and unstable angina, not vasospastic, decreased death due to MI, good for pt with htn and as a combination to decrease reflex tachy
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contraindications of bb
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bradycardia, sick sinus syndrome, LV failure
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