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20 Cards in this Set
- Front
- Back
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Mixed cryoglobulinemia is associated with ? and ?
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HEPATIS C
autoimmune disorders generally also chronic infections |
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In addition to palpable purpura, what are symptoms of mixed cryoglobulinemia?
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urticaria
glomerulonephritis hepatosplenomegaly lymphadenopathy arthralgia CHRONIC RENAL DISEASE over the long run |
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What labs would you order for suspected mixed cryoglobulinemia?
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1. complement, look for hypo-complementemia
2. LFTs - should be elevated 3. cryoglobulin titer 4. check Hep C |
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Don't confuse cryoglobulins with cold agglutinins. Cold agglutinins are associated with what diseases?
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measles
mumps mono mycoplasma mmmmmmm cold ice cream |
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What are cold agglutinins?
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IgM antibodies to RBCs
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What are the criteria for diagnosing antiphospholipid syndrome?
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One clinical and one lab finding:
1. clinical: a thrombotic event, one miscarriage > 10 weeks or three < ten weeks, or one premature birth < 34 weeks b/c of pre-eclampsia or placental insufficiency 2. Lab: 2 measures of antiphospholipid antibodies 12 weeks apart, or one direct measure of lupus anticoagulant |
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What is the least reliable antiphospholipid for establishing the syndrome?
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anticardiolipin antibody
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#1 clinical sx of Takayasu's
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bruits
more common than uneven pulses, etc. |
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mnemonic for PAN facts
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PPPPPAN-M-B
Platelets elevated polymyositis parvovirus and others p-ANCA positive PURPURA Arthropathies Nephritis (GN mc sx) Mononeuritis multiplex (mc sx) myalgias, arthralgias medium vessel vasculitis Hep B |
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mnemonic for cryoglobulinemia facts
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Cryoglobulinemia
Complement low Hepatitis C associated, rule out |
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Hep B is associated with what vasculitis?
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PAN
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Hep C is associated with what vasculitis?
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cryoglobulinemia
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Hairy cell leukemia is associated with what vasculitis?
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PAN
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Does PAN have low complement?
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in 25% of cases
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Medications that can cause PAN
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allopurinol, sulfa drugs
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Most common area of claudication in Buerger's is ?
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instep
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Buerger's is treated like what other condition?
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Raynaud's (CCBs, IV prostaglandins)
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Chrug-Strauss is [c-ANCA, p-ANCA]
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p-ANCA
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Steroids are not the sole treatment of Wegner's. What else?
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cyclophosphamide (for one year)
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Classic weird symptom of Wegener's
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saddle nose
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