A. Pharm Receptors

Front 1

What are the NT's of the ANS?

Back 1

Ach and NE

Front 2

What happens to the SM when you denervate the ANS?

Back 2

SM still shows spontaneous activity

Front 3

What are the divisions of the ANS?

Back 3

SANS and PANS

Front 4

What do the ions Na, Ca, Cl and K do to action potential?

Back 4

1. Ca and Na = EPSP
2. K and Cl = IPSP

Front 5

How do you terminate postjunctional activity?

Back 5

1. Enzymatic destruction
2. Reuptake into presynaptic cell or associated structures

Front 6

What four drugs affect the Ach synthesis, storage and release?

Back 6

1. Hemicholinium
2. Vesamicol
3. Botulinum
4. Latrotoxin

Front 7

What three drugs affect the NE synthesis, storage and release?

Back 7

1. Metyrosine
2. Reserpine
3. Guanothiodine

Front 8

What are the nicotinic receptors and their effectors?What are their postreceptor mechanism?

Back 8

1. Nn = nerve nerve
2. Nm = nerve/ SM
3. Both open cation channels
4. ionotropic

Front 9

What are the M1, M2 and M3 receptors? What are their postreceptor mechanism?

Back 9

1. Ganglionic, CNS neurons(IP3/DAG)
2. Myocardium( down cAMP, open K)
3. SM, Exocrine glands, and vascular endothelium (IP3/DAG)
4. Metabotropic

Front 10

What are the effects of M2 receptros?

Back 10

1. Decrease myocardial rythm
2. Autonomic nerve endings(NE and Ach release)

Front 11

What are the effects of M3 receptors?(11)

Back 11

1. Dialate arterioles, GI motility
2. Urination
3. Uterine Contration
4. Miosis
5. Bronchoconstriction
6. Erection
7. Lacrimation
8. Salivation

Front 12

What does DUMBBELSS stand for?

Back 12

1. Defecation
2. Urination
3. Miosis
4. Bradycardia
5. Bronchoconstriction
6. Excitatory CNS and SKM
7. Lacrimation
8. Salivation
9.Sweating

Front 13

What is the RLS in NE synthesis?

Back 13

1. Tyrosine Hydroxylase

Front 14

What metabolizes NE and E? What is the metabolite? What is the metabolite of DA?

Back 14

1. COMT and MAO
2. VMA
3. HVa

Front 15

What do the Alpha 1 and 2 receptors do?

Back 15

1. Vascular SM, Visceral SM sphincters, iris(IP3/DAG)
2. Pacreas beta cells, platelets, SM(down cAMP, open K)

Front 16

What do the Beta 1,2 and 3 receptors do and their 2nd messengers?

Back 16

1. Myocardium, JG cells ( inc cAMP)
2. Visceral SM, vascular SM, liver, SKM ( increase cAMP)
3. Adipocytes(increase cAMP)

Front 17

What do the DA receptors do?

Back 17

1. DA 1 increase cAMP and affects the Renal secretion of Renin therefor the vascular SM

Front 18

What is the order of importance of biogenic amine receptors in vascular SM?

Back 18

1. Alpha 1
2. Beta 2
3. D - 1

Front 19

What drug inhibits NE reuptake?

Back 19

Cocaine

Front 20

What does Yohimbine do? What does albuterol do?

Back 20

1. Blocks alpha 2-R (ED)
2. Activates Beta 2-R(bronchodialation)

Front 21

What do the Beta 1 receptors do in the heart? In the ventricles?

Back 21

1. Tachycardia
2. Increase contracitillty

Front 22

What do the adrenergic impulses do the arterioles and veins?(2)

Back 22

1. Beta-2 dialation of SKM, coronary, and liver
2. Alpha 1 constriction of visceral

Front 23

What do the adrenergic impulses do to the lungs?(2)

Back 23

1. Beta-2 Bronchodialates
2. Alpha 1 decrease secretions

Front 24

What do the adrenergic impulses do to the skin?

Back 24

1. alpha 1 erector pili and apocrine sweat glands(hair smell)

Front 25

What do the adrenergic impulses do to the platelets and mast cells? And fat cells?

Back 25

1. Alpha-2 aggregation
2. Beta-2 inhibit degranulation
3. Beta 3 lipolysis

Front 26

What do the adrenergic impulses do to the sex organs?

Back 26

1. alpha 1 erection
2. beta 2 uterine relaxation

Front 27

What do the adrenergic impulses do to the GI?(2)

Back 27

1. Beta thick secretion
2. Alpha 1 sphincter contration

Front 28

What do the adrenergic impulses do to the GB and Liver? Pancreas?

Back 28

1. Beta 2 relaxation
2. Glygenolysis and gluconeogenesis
3. Alpha 2 decrease insulin and beta increase glucagon

Front 29

What do the adrenergic impulses do to the kidney?

Back 29

1. Trigone contraction

Front 30

What do the adrenergic impulses do to the eye? To the sympathetic nerve endings?

Back 30

1. Beta 2 increase aqueous humor
2. Alpha 2 decreases ACh
3. Beta 2 Increases NE

Front 31

adrenergic impulses do to the SKM?

Back 31

1. Beta -2
2. Ca sequesteration, glycogenolysis, K uptake

Front 32

Describe the four steps of ganglionic neurotransmission?

Back 32

1. Ach to Nn = EPSP
2. Ach to M2 = Small intense flourescent opens K channels = IPSP
3. Ach to M1 = IP3/DAG slow EPSP
4. Peptides decrease K = Late EPSP

Front 33

What do the alpha 1 receptors do?(5)

Back 33

1. VasoC
2. Increase peripheral resistance
3. Increase BP
4. Mydriasis
5. Close internal bladder sphincter

Front 34

What do the alpha 2 receptors do?(2)

Back 34

1. Inhibit NE release
2. Inhibit Insulin release

Front 35

What do the Beta 1 receptors do?(4)

Back 35

1. Tachycardia
2. Lipolysis
3. Myocardial Contractility
4. Renin release

Front 36

What do the Beta 2 receptors do?(6)

Back 36

1. VasoD
2. Slightly decrease peripheral resistance
3. BronchoD
4. Increase glycogenolyisis in muscle and liver
5. Increase Glucagon
6. Relax uterine SM