A. Antimuscarinic And Ganglionic Drugs

Front 1

What are the tertiary amines for anti muscarinics?(5)

Back 1

1. Atropine
2. Scopolamine
3. Homatropine
4. Tolterodine
5. Trihexophenydil

Front 2

What are the quarternary antimuscarinic drugs?(2)

Back 2

1. Glycopyrrolate
2.Ipratopium

Front 3

What are the ganglionic stimulants? Blockers?

Back 3

1. Nicotine
2. Mecamylamine

Front 4

What are the natural antimuscarinincs?(2)

Back 4

1. Atropine
2. Scopolamine

Front 5

What are the MOA of antimuscarinics?

Back 5

1. Competitively block muscarinic receptors
2. Atrpopine and Scopolamine block them all while others may have selectivity
3. Tertiary ones do not block Nn, but quaternary do

Front 6

Where does tolterodine block?

Back 6

1..M3 receptors only

Front 7

What does atropine effect?(3)

Back 7

1. M2 heart, LSS blocked at low
2. everything as well as the Eye, and CNS depression at normal levels
3. All DUMBBELSS to the extereme REVERSE and atropine psychosis

Front 8

Atropine and Scopolamine do what after intermediate doses in the CNS?(2)

Back 8

1. Inc heart rate
2. Reduces parkisonia tremor and rigidity

Front 9

Atropine and Scopolamine do what to the CV system?

Back 9

1. At low they decrease HR ?
2. At intermediate they Tachycardia
3,Nothing to the ventricles or circulation
4. At high doses dilation of cutaneus vessels and Atropine flush

Front 10

Atropine and Scopolamine do what to the GI?

Back 10

1. Decreased gastric acid moderately
2. relaxation of LES
3. Slow the GI

Front 11

What do the antimuscarinics Atropine and scopolamine do to the lungs?

Back 11

1. Bronchial SM relaxation
2. Decrease secretions
3. Decrease Mucociliary clearance except Ipratropium

Front 12

What do atropine and scopolamine do to the Eye and Skin?

Back 12

1. Dialation of 3 days or more and decrease tears(dry)
2. Decrease sweat gland secretion, gives children atropine fever

Front 13

Where are the quarternary and tertiary antimuscarinics distributed?

Back 13

1. Tertiary in all tissues
2. Quarternary not in the CNS

Front 14

Where are the antimuscarinics excreted?

Back 14

1. 60% in the kidney
2. The rest is metabolize
3. Atropine and Scopolamine 3 hours
4. Glycopyrrolate = 10 hours

Front 15

What is the dangers of antimuscarinics in children?

Back 15

1. Adults have large therapeutic index >100
2. Children it's less than 5

Front 16

When do you see SS of antimuscarinic poisoning? Why death? What's the Tx for each symptom?

Back 16

1. 1 hr you see it
2. 2-7 days it lasts
3. Death from respiratory failure
4. Tx is symptomatic(Vitals, Convulsions, Temperature)

Front 17

What are the effects of antimuscarinic poisoning?(5)

Back 17

1. Hot as a hare
2. Dry as a bone
3. Mad as a hatter
4. Red as a beet
5. CNS effects

Front 18

What are the therapeutic indications for antimuscarinics in the eye?

Back 18

1. Fundoscopic exam
2. Iritis

Front 19

What are the therapeutic indications for antimuscarinics in the GI?(4)

Back 19

1. IBS
2. Abdominal Colic
3. Diarrhea(traveler's dz)
4. Sialorrhea(saliva) from parkinsons or heavy metal poisoning

Front 20

What are the therapeutic indications for antimuscarinics in the respiratory system?

Back 20

1. Asthma and COPD with Ipratropium

Front 21

What are the therapeutic indications for antimuscarinics in the CV system?(3)

Back 21

1. CPR
2. Bradycardia
3. AV block(no 3rd)

Front 22

What are the therapeutic indications for antimuscarinics in the CNS? and others?(4)

Back 22

1. Motion sickness with scopolamine
2. Parkinson's Trexyphenydil
3. Counteract Neostigmine in myasthenic patients
4. Mushroom poisoning

Front 23

What do you use atropine for?(6)

Back 23

1. Visceral Spasms
2. Excess salivation
3. CV disorder
4. Opthamology
5. ACH-E overdose
6. Preanesthetic

Front 24

What is scopolamine used for?(3)

Back 24

1. Motion sickness
2. Opthamollogy
3. Preanesthetic

Front 25

What is trihexyphenidyl used for?

Back 25

Parkinson's

Front 26

What is glycopyrrolate used for?

Back 26

1. Visceral spasm
2. CV disorder
3. Preanesthetic

Front 27

What is iprtropium used for?

Back 27

1. Brochospastic disorders

Front 28

What are the ganglionic stimulating drugs?(2 main and 2 others)

Back 28

1. Nicotine
2. Tetrametylammonium
3. Carbachol
4. Succinylcholin

Front 29

What are the ganglionic blocking drugs?(2 main and 2 others)

Back 29

1. Hexamethonium
2. Mecamylamine
3. Glycopyrrolate
4. Ipratropium

Front 30

What does nicotine do at large doses?

Back 30

1. Depolarization blockade that hinders neuronal transmission

Front 31

What sensory receptors does nicotine hit?

Back 31

1. Mechano receptors of the mesentery, tongue, stomach, lung and skin
2. Chemoreceptors in carotid
3. Thermal receptor in skin and tounge
4. Pain receptors

Front 32

What are the effects of nicotine in the CNS?(5)

Back 32

1. Reflex emetic center stim
2. Direct CTZ(Vomitting)
3. Stim ADH
4. Stim attention and memory at low doses
5. Hyperreflexia, convulsion and tremors at high doses

Front 33

What are the effects of nicotine in the in the CV system?(3)

Back 33

1. Increase CO and HR
2. Dialation of muscle vessels and constrict skin and sphlanic vessels
3. CV collapse after toxic doses

Front 34

What are the effects of nicotine in the respiratory system?

Back 34

1. Bronchoconstriction and increased secretions
2. Apnea at toxic doses

Front 35

What are the effects of nicotine in the Urinary system?

Back 35

1. Decreased diuresis

Front 36

What are the therapeutic uses of ganglionic blocking drugs?

Back 36

1. Mecamylamine for Tourette's
2. Possible for cocaine and nicotine dependence