A

Front 1

Hypotension, pressor agent α / β1 β3 (β2) neuronal, non-circulating, I:MAOI, TCA

Back 1

Norepinephrine

Front 2

Allergic reactions, shock, CPR α / β1 β2 (β3) adrenal medulla, circulate; I: maoi,TCA

Back 2

Epinephrine

Front 3

Renal vasodilatation during shock α1 / β1 / D, precursor to NE, I: MAOI

Back 3

Dopamine

Front 4

Asthma, cardiac stimulant β, synthetic, not endogenous; BP(↓, --) HR↑

Back 4

Isoproterenol

Front 5

Selective alpha1-agonists, Nasal decongestant, hypotension, Not commonly used for hypotension;S: CV, reflex bradycardia

Back 5

Phenylephrine

Front 6

Selective alpha2-agonists, Hypertension, Opioid withdrawal, α2, ↓ cns sympathetic outflow, inhibit NE release,rebound HT; S: dry mouth, sedation, impotence.α-methyl-dopa is metabolized to α-methyl-NE (α2-agonist, positive Coombs test)

Back 6

Clonidine

Front 7

bad part of B2 agonist with heart

Back 7

(↑HR, ↓BP)

Front 8

Selective beta2-agonists

Back 8

albuterol

Front 9

CHF, cardiac stimulant, Increase force, no change in HR or oxygen demand β1, iv infusion, tolerance, desensitization,

Back 9

Dobutamine

Front 10

Premature labor, β2--selective

Back 10

Ritodrine

Front 11

Parkinson’s disease precursor to DA, cross to CNS

Back 11

L-Dopa

Front 12

Nasal decongestant, red eyes α /β, also indirect to release NE; I: AOI, TCA

Back 12

Ephedrine

Front 13

Narcolepsy, hyperactivity, [obesity], Indirectly-acting Sympathomimetics (Displaces NE), CNS stimulant, requires uptake1,can cause tolerance, tachyphylaxus

Back 13

Amphetamine

Front 14

Hyperactivity disorder (ADHD), Indirectly-acting Sympathomimetics (Displaces NE), CNS stimulant, requires uptake1,can cause tolerance, tachyphylaxus

Back 14

Methylphenidate

Front 15

Desensitization of ampedamines by rapid depletion

Back 15

Tachyphylaxis

Front 16

None, [high] in red wine & cheese interaction with MAO inhibitors,

Back 16

Tyramine

Front 17

MAOI and Tyramine Crisis Treatment

Back 17

Treat increased Ht rate and BP with Albha blocker or alpha/beta blocker labetalol

Front 18

Inhib neruonal uptake 1 on NE

Back 18

Cocain, TCA(Imipramine, amitriptylline

Front 19

if take cocane before amphedamine

Back 19

amphetamine not work bc uptake inhibited

Front 20

Pheochromocytoma, acute, chronic HT α1, irreversible, S: PHT

Back 20

Phenoxybenzamine

Front 21

Pheochromocytoma, acute HT α, competitive, S: PHT, reflex tachycardia

Back 21

Phentolamine

Front 22

Hypertension (HT), benign prostrate hypertrophy α1, competitive; no reflex tachycardia S: 1st pass effect, PHT, nausea, drowsiness

Back 22

Prazosin

Front 23

Hypertension, angina, arrhythmias, tremor,migraine, hyperthyroidism (propranolol),panic stress β, non-selective, LA-action, no ISA; Useful group, CI:heart failure (unstable CHF, depression, bradycardia or brochospasm), asthma, diabetes, Raynaud D

Back 23

Propranolol

Front 24

Hypertension, angina, arrhythmias β, LA-action, ISA, angina commonly

Back 24

Pindolol

Front 25

Glaucoma, decrease secretion; (HT) β, no LA-action, no ISA, glaucoma commonly

Back 25

Timolol

Front 26

Hypertension, angina, arrhythmias, CHF β1, LA-action, no ISA, arrhythmia commonly

Back 26

Metoprolol

Front 27

Hypertension, angina β1, no LA-action, no ISA

Back 27

Atenolol

Front 28

Arrhythmias, [angina] β1, no LA-action, no ISA, very short acting

Back 28

Esmolol

Front 29

Hypertensive crisis, hypertension, CHF β & α -blocker, some β-agonist action

Back 29

Labetalol

Front 30

Hypertensive crisis, hypertension, CHF β & α -blocker

Back 30

Carvedilol

Front 31

inhibit neuronal uptake, cross CNS; I: CA's, amph.

Back 31

Cocaine

Front 32

Attention deficient hyperactivity (ADHD) inhibit NE neuronal uptake

Back 32

Atomoxetine

Front 33

No major use, minor ocular procedures for brief miosis; muscarine found in certain mushrooms M / N, short acting (AchE); T/S: All M-agonists: salivation, lacrimation, urination, diarrhea, emesis, (slude), miosis, cyclopleg, bronchoconstriction, ↓HR

Back 33

Acetylcholine

Front 34

Atonic gut, urinary retention M, resistant to AchE

Back 34

Bethanechol

Front 35

Acute & chronic glaucoma M, resistant to AchE; alkaloid, increase outflow

Back 35

Pilocarpine

Front 36

Glaucoma, if pilocarpine ineffective M / some N, resistant to AchE

Back 36

Carbachol

Front 37

Ocular procedures M, resistant to AchE

Back 37

Methacholine

Front 38

Diagnostic for myasthenia gravis competitive, short-acting (5-10min)

Back 38

Edrophonium

Front 39

Myasthenia gravis, reverse nmj block reversible, no CNS, some direct agonist action

Back 39

Neostigmine

Front 40

Myasthenia gravis AchE inhibitors occupy AchE and prevent Ach degradation, T/S: same as for high Ach

Back 40

Pyridostigmine

Front 41

Reverse atropine toxicity; glaucoma reversible, CNS action

Back 41

Physostigmine

Front 42

Organophosphate, Glaucoma (also cause miosis, cycloplegia)

Back 42

DFP (Isoflurophate)

Front 43

Glaucoma (also cause miosis, cycloplegia

Back 43

Echothiophate

Front 44

Insecticides (Inactive, converted to active, form in body, parathion more toxic)

Back 44

Malathion, Parathion

Front 45

(nerve gases

Back 45

Vx, sarin, soman

Front 46

↓GI activity, ↓secretions, relax lung, mydriasis (pupil dilation), cyclopegia (loss of accommodation), competitive M-antagonists, pirenzepine (M1- selective); T: mad as a hatter (unresponsive), red as a beet (erythematous, direct vasodilation), blind as a bat (cycloplegia), dry as a bone (↓secretions), hot as hell (thermoregulation); Reverse toxic effects with AchE inhibitors eg. physostigmine or neostigmine. Horner’s S.: miosis, sagging eyelid. Damage to sympathic innervation, no cocaine response, pre- (Tyr response) or post-ganglionic (no Tyr response)

Back 46

Cholinoceptor Antagonists

Front 47

Reverse AChE inhibition; GI-disorders, ocular (iritis), vagolysis

Back 47

Atropine

Front 48

Asthma – bronchodilator

Back 48

Ipratropium

Front 49

Parkinson's disease, esp. drug induced

Back 49

Benztropine

Front 50

Motion sickness, diarrhea, ↓secretions

Back 50

Scopolamine

Front 51

GI-disorders ie. mild diarrhea, [peptic ulcer

Back 51

Propantheline

Front 52

Ocular examination

Back 52

Cyclopentolate

Front 53

inhibit choline uptake (rate limiting step)

Back 53

Hemicholinium

Front 54

↓Ach release (prevent vesicle fusion), 3-4 mths

Back 54

Botulinus toxin

Front 55

Regenerate AchE need to use before ‘aging’ occurs

Back 55

Pralidoxime, (2-PAM)

Front 56

Insecticide, cigarettes N-agonist, (blocker) T: convulsions, vomiting, CV

Back 56

Nicotine,

Front 57

↓ BP during surgery, Nn-antagonists, (competitive), not taken orally

Back 57

Trimethapan

Front 58

↓ BP during surgery, Nn-antagonists, (competitive), taken orally

Back 58

Mecamylamine

Front 59

NMJ paralysis, depolarizing block, short acting due to plasma AchE; fasciculations, Atypical AchE, Malignant H, Hyperkalemia (delayed)

Back 59

Succinylcholine

Front 60

NMJ paralysis, competitive blockers, Small/fast nerves first (face, hands), then trunk, respiratory muscles last. Flaccid paralysis. Can reverse block with AchE inhibitors -Nm, some histamine release & ganglia block

Back 60

Tubocurarine

Front 61

NMJ paralysis, competitive blockers, Small/fast nerves first (face, hands), then trunk, respiratory muscles last. Flaccid paralysis. Can reverse block with AchE inhibitors -short acting 10-20 min, slight histamine release

Back 61

Mivacurium

Front 62

NMJ paralysis, competitive blockers, Small/fast nerves first (face, hands), then trunk, respiratory muscles last. Flaccid paralysis. Can reverse block with AchE inhibitors

Back 62

Rocuronium,

Front 63

Prostaglandin, Glaucoma, ↑ outflow. S: brown pupil, red eyes (inflammation)

Back 63

Latanoprost (PGF2α analogue) (Xalatan

Front 64

Acute hypersensitivity reaction ie. bee attack, food or drug reaction α- β-agonist, physiologically counters the effects of released histamine (ie. bronchospasm, ↓BP)

Front 65

Vascular smooth muscle contract, contract radial dialator muscle, contract Piomotor, EPI>NE>>>ISO

Back 65

α1-

Front 66

Nerve terminals , inhib neurotrans release, neg feedback, NE>>EPI>>>ISO

Back 66

α 2-

Front 67

Cardiac muscle, Increase HR and force, Dilate Coronayr Blood Vesil, Release Renin from kidney, ISO>>NE & EPI

Back 67

β 1-

Front 69

Bronchial smooth muscle relax, also relax all tubes (GI, Blood Vesil, Urinary), Has pos feedback on nerve terminal, ISO>EPI>>>NE

Back 69

β2

Front 70

fat

Back 70

β3

Front 71

Renal smooth muscle (D1-)

Back 71

dopamine receptor

Back 72

M1

Back 73

M2

Front 74

symp. nerve, placenta

Back 74

(MAOA)

Front 75

platelets

Back 75

(MAOB)

Front 76

liver, kidney, brain

Back 76

(MAOA + MAOB)

Front 77

increases NE level in symp. neuron, potentiates release by tyramine-like drugs

Back 77

Effect of MAO inhibition on NE levels

Front 78

Depression Tranylcypromine, Pargyline

Back 78

MAO Inhibitors: Non-selective

Front 79

Depression MAO-A Clorgiline, Parkinson’ D MAO-B Selegiline

Back 79

MAO Inhibitors: Selective

Front 80

MOPEG then to VMA

Back 80

MAO or compt metab NE to what found in urine?