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9 Cards in this Set
- Front
- Back
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What is DNA Nucleotide Excision Repair?
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Specific endonuclease cuts specific segment out, fills correct segment in
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Which disease has a mutation of the DNA nucleotide excision repair?
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Xeroderma Pigmentosum, prevents repair of pyramidine dimers from UV light exposure
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What is DNA Base Excision Repair?
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Specific glycosylases recognize and remove damaged bases
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Why is DNA base excision repair important?
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Repair of spontaneous/toxic deamination
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What is DNA mismatch repair?
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Newly synthesized strand is recognized, mismatched nucleotides are removed and the gap is filled and resealed
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What disease has mutated mismatch repair?
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Hereditary Nonpolyposis Colorectal Cancer
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What is nonhomologous end joining?
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Brings together 2 ends of DNA fragments to repair double-stranded breaks
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What disease has mutated nonhomologous end joining?
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Ataxia Telangiectasia
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What is DNA/RNA/protein synthesis direction?
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Both DNA and RNA synthesized from 5'-3' direction, triphosphate bond is the target of the 3' hydroxyl attack
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