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25 Cards in this Set
- Front
- Back
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What is measured for Growth Hormone deficiency diagnosis?
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GHRH
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What is used for treating GH deficiency?
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rGH - recombinant
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What is used for treatment of acromegaly?
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Octreotide
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Octreotide is:
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Somatostatin analog
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What is used for treatment of acromegaly if not an SST analog?
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Pegvisomant
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Pegvisomant is:
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GH receptor antagonist
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How is GH release from the pituitary regulated? (pos vs neg)
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Pos: stim by GHrH from hypothal
Neg: inhib by SST from hypothal |
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What inhibits GHRH release from the hypothal?
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GH negative feedback
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What stimulates SST release from the hypothal?
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IGF1 from the liver
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Where did IGF1 from the liver come from?
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Stimulation by GH from the pituitary
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How is GH deficiency diagnosed?
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By injecting GHRH and looking for the responsive GH production
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What will be the result of GHRH injection in a GH deficient patient?
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Subnormal GH release from the pituitary
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When will a kid with GH deficiency start to fall off the growth curves?
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Between the age of 1-3
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What drug is used for treating GH deficiency?
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hGH - human or recombinant GH
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What is used for treating Acromegaly?
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Octreotide
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What is Octreotide?
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A somatostatin analog
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What is another SST analog?
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Lanreotide
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What does an SST analog do?
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inhibits the pituitary so that GH release is decreased
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What causes acromegaly?
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GH secreting pituitary adenomas
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What is measured to diagnose acromegaly?
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IGF1 levels
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What are 2 things that Octreotide does in treating GH-secreting pituitary adenomas?
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-Inhibits GH release
-Shrinks the tumor to allow for better surgical resection |
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What is a last resort treatment for Acromegaly?
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Pegvisomant
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What is Pegvisomant?
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GH-receptor antagonist
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What is achieved by antagonism of GH receptors?
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It inhibits GH from stimulating liver production of IGF1 so the levels of IGF1 are decreased
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Why is pegvisomant a last resort?
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Because by blocking IGF1 production, it reduces SST from hypothal, so that it may actually increase pituitary GH release and tumor size.
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