8/24/10 Capillary Filtration

Front 1

Using the starling equilibrium equation for capillary filtration, describe the forces that alter fluid movement across a capillary.

Back 1

NFP = kf [(Pc-Pif) – σ(πc – πif)]

NFP = in the direction of out of the capillary

Kf = capillary filtration coefficient dependent on molecules and membrane
Pc going into interstitium
πc going into interstitium

Front 2

Describe how inflammation can alter capillary permeability

Back 2

Histamine : a little = increased flow (distends vessel)
A lot = decreased pressure (anaphalaxis)
2. Cytokines (alters flow/pressures and permeability)
3. Drugs: anything influencing contraction or dilation of smooth muscle and endothelial permeability
4. Nerves: Sympathetic
5. Inflammation: Stretches the cells apart increase cleft size

Front 3

Explain how an increase in permeability can increase fluid and solute movement out of a capillary

Back 3

Proteins

Front 4

Describe how endogenous compounds released can alter capillary permeability.

Back 4

Histamine, Cytokines

Front 5

Explain how protein leakage from capillaries can result in edema.

Back 5

Osmotic pressure difference

Front 6

Third spacing of fluids, decrease of blood pressure, introduce concept of shock

Back 6

SHOCK: Low Blood pressure causing a lack of blood flow to vital tissues

Front 7

Which of the following is altered by the body to increase capillary filtration?

Blood pressure
Permeability
Osmotic pressure
Lymphatic pressure

Back 7

Permeability