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40 Cards in this Set
- Front
- Back
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What are 7 diseases of childhood and adolescence? What are the causative agents of each?
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1. Measles - Rubeola virus
2. Mumps 3. Mono - EBV 4. Poliovirus 5. Chicken pox - VZV 6. Whooping cough - Bordatella pertussis 7. Diphtheria - C. diphtheriae |
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So what is the viruse that causes measles?
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Rubeola
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What is the oral cavity sign of measles?
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Koplik spots
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When does Measles become deadly?
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When it turns into pneumonia
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What type of cells in the lungs are diagnostic of Measles?
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Warthin-Finkeldy giant cells
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Is there a vaccine available for measles?
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Yes
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What is the nonsystemic manifestation of measles?
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Blotchy reddish brown rash on the face, trunk, and proximal extremities.
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What is the causative agent of MUMPS?
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Paramyxovirus
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What is Mumps?
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A transient inflammation of the parotid glands
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Does mumps only cause inflammation of the parotid glands?
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No it can also be see in the testes, ovary, and pancreas.
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How is Mumps transmitted?
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By respiratory droplets
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Is there a vaccine for mumps?
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yes
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What is the causative agent of Chicken pox?
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Varicella zoster virus VZV
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How is VZV transmitted?
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By aerosol droplets
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How does VZV disseminate in the body?
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Hematogenously
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What is the physical manifestation of VZV?
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Widespread cutaneous lesions
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How does VZV get into the CNS to set up latency?
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Via infection of satellite cells in the DRG
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What are the intranuclear inclusions seen in VZV identical to?
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Those seen in Herpes
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Why are the vesicles that erupt on the skin in chickenpox dangerous?
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They are susceptible to secondary infection because the vesicular clear fluid is very itchy.
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What is Shingles?
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The reactivation of a latent form of VZV in the dorsal root ganglia
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Why is Shingles so painful?
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Because it affects specific dermatomes based on the level of drg infected.
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What is VZV a member of?
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The human Herpesvirus family
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What are the 7 important human herpesviruses to know?
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-HSV1
-HSV2 -VZV -EBV -CMV -HHV6 -HHV8 |
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What does HSV1 cause?
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ORAL skin and mucosal vesicles and ulcers
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What does HSV2 cause?
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GENITAL skin and mucosal vesicles and ulcers
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What does VZV cause?
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Chickenpox and shingles
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What does EBV cause?
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Infectious mono
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What does CMV cause?
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Infections in immunocompromised patients and Congenital infections.
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What does HHV6 cause?
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Exanthema subium in infants
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What does HHV8 cause?
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Kaposi's sarcoma
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How are human herpesvirus infections diagnosed? Why?
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Via serology - because of the latency period that makes culture impossible.
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What can happen in immunocompromised hosts with herpesvirus infections?
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Dissemination to the brain
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What are the cytopathic features of Human herpesvirus infections?
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-Cowdry type A intranuclear inclusion bodies
-Multinucleate giant cells |
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What is the characteristic arrangement of the heterochromatin in Herpesvirus multinucleate giant cells?
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Peripheral
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What type of symptoms does CMV cause in HEALTHY people?
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-Asymptomatic
or -Mono-like illness |
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What does CMV do to neonates and immunosuppressed patients?
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Causes DEVASTATING infections
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What does CMV do once inside a host?
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Remains latent in leukocytes
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What are the 3 pathologic features of CMV?
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-Focal necrosis
-Minimal inflammation -Cytopathic changes |
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What is West nile virus?
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Arbovirus
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What transmits West nile virus?
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Mosquitoes to birds and mammals
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