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27 Cards in this Set
- Front
- Back
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How many atypicals are there and what is the acronym?
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6 - A Zinfindel CORQ
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What is A Zinfindel CORQ?
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-Aripiprazole
-Ziprasidone -Clozapine -Olanzapine -Risperidone -Quetiapine |
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What is different about the atypicals compared to the typicals?
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They block both D2 and 5HT2 receptors so treat the neg symptoms better
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Which of the atypicals is most potent and effective?
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Clozapine
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What is clozapine reserved for?
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Treating patients with refractory schizophrenia
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Which type of DA receptors does Clozapine act on more?
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D4 more than D2 (both are D2 type receptors)
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How do the EPS symptoms caused by clozapine compare to the other atypicals?
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Fewer and less severe
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What are the 2 main reasons Clozapine is only used for refractory patients?
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-Lowers the seizure threshold
-Can cause fatal agranulocytosis |
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But the 2 good things about Clozapine are?
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-Treats both pos/neg symptoms
-Causes fewer EPS |
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What atypical is related to Clozapine but doesn't work as well?
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Olanzapine
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What is probably the reason that Olanzapine doesn't work as well as Clozapine?
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Olanzapine is a more potent antagonist of 5HT-2 receptors than DA receptors
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But what makes Olanzapine attractive as an atypical
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It doesn't cause agranulocytosis doesn't cause much EPS, and doesn't cause as much seizures
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What atypical is similar in its antipsychotic and side effects to both Clozapine and Olanzapine?
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Risperidone
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What does Risperidone block?
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Both DA and 5HT3 receptors
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Which of the 3 similar atypicals is use most commonly? Why?
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Risperidone - not only does it produce few EPS, it treats the neg symptoms better and is sedating
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What are the top 3 drugs drugs of choice for the treatment of a first episode of schizophrenia?
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-Risperidone
-Haloperidol -Olanzapine |
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What drug is structurally related to Clozapine and has effects on D2 and 5HT2 receptors?
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Quetiapine
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What is unique about Quetiapine?
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Short t1/2
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What drug is a 5HT1a agonist in addition to blocking 5HT2 and D2?
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Ziprasidone
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What effect does agonism of the 5HT1a receptor have?
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Anxiolytic
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What is a good thing about Ziprasidone?
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No weight gain
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What atypical is a D2 partial agonist?
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Aripiprazole
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How does Aripiprazole treat schizophrenia if it's an AGONIST of DA receptors?
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Partial agonism antagonizes the effects of endogenous DA at places where it's too high, but not at places where it's low
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So what are the 5 main clinical uses of the antipsychotic drugs?
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MCATA
-Manic episodes -Chronic schizophrenia -Acute psychotic episodes -Tourette's syndrome -Antiemesis |
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What is the drug of choice for treating Tourette's?
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Haloperidol
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What is the 2nd choice drug for tourette's?
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Pimozide
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Which antipsychotic would NOT be useful as an antiemetic?
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Thioridizine
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