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16 Cards in this Set
- Front
- Back
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dissociation of water is described by
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ion product Kw
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Kw= [conc?] =?
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[OH-][H+]=1 X (10^-14) M2
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M for pure water/any neutral soln
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10^-7
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tendency to lose a proton
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dissociation constant, Ka
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Ka= [conc?]
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[H+][A-] / [HA]
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relationship b/w pH and pKa (equation)
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pH = pKa + log [A-] / [HA]
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pKa = (in relationship to Ka)
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= - log Ka
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when weak acid = ionized,
what is relationship b/w [HA] AND [A-] |
[HA] = [A-]
pH=pKa |
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buffer
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soln of a weak acid and its conjugate base
that resists changes in pH |
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where does a buffer have minimum buffering capacity
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@pKa of its weak acid
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pI or iso-electric point
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the pH at which net charge on an a.a. or protein is zero (number of pos and neg charges = zero)
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an amino acid is (neg/pos) charged below its pH
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pos
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3 feature of molecules @ pI
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1. repel ea. other (solubility at minimum)
2. won't migrate in electric field (= no electrophoresis) 3. wont bind to ion xchange column |
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effect of solubility on pI
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minimum
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relationship b/w strong acids and Ka
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strong acids = large Ka
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relationship b/w strong acids and pKa
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strong acids have small pKa values
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