Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
18 Cards in this Set
- Front
- Back
|
What is the mechanism for Zanamivir and Oseltamivir?
|
Inhibits influenza neuraminidase, decreasing release of progeny virus
|
|
|
What are Zanamivir and Oseltamivir used to treat?
|
Prophylaxis of Influenza A
Influenza A and B H5N1 H1N1 |
|
|
What is the mechanism for Ribavirin?
|
Inhibits synthesis of guanine neucleotides by competitively inhibiting IMP dehydrogenase
|
|
|
What is Ribavirin used to treat?
|
RSV (+ Interferon alpha)
Chronic Hepatitis C |
|
|
What are the 2 toxicities of Ribavirin?
|
Hemolytic Anemia, teratogen
|
|
|
What is the mechanism for Acyclovir?
|
Monophosphorylated by HSV/VZV thymidine kinase
Inhibits viral DNA polymerase by chain termination |
|
|
What are the uses for Acyclovir?
|
HSV 1+2
VZV Weak against EBV NO ACTIVITY AGAINST CMV |
|
|
What do you use instead of Acyclovir for Herpes Zoster?
|
Famciclovir
|
|
|
What is the mechanism for Ganciclovir?
|
5' monophosphate formed by CMV viral kinase
Preferentially inhibits viral DNA polymerase |
|
|
When do you use Ganciclovir?
|
CMV - especially immunocomprimised patients
|
|
|
What is a prodrug of Ganciclovir that has better oral bioavailability?
|
Valganciclovir
|
|
|
What are the toxicities of Ganciclovir?
|
Leukopenia, neutropenia, thrombocytopenia, renal toxicity
|
|
|
What is the mechanism of action for Foscarnet?
|
Viral DNA polymerase inhibitor
DOES NOT require activation by viral kinase |
|
|
When do you use Foscarnet?
|
CMV retinitis in immunocompromised patients
Use when Gancyclovir fails |
|
|
What is the toxicity of Foscarnet?
|
Nephrotoxicity
|
|
|
What is the mechanism for Cidofovir?
|
Inhibits viral DNA polymerase
|
|
|
When do you use Cidofovir?
|
CMV retinitis in immunocompromised patients, acyclovir resistant HSV
|
|
|
What is the toxicity of Cidofovir?
|
Nephrotoxicity
|
